alcohol dehydrogenase, iron-containing
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   1ebh(B) : AVSKVYARSVYDSRGNPTVEVELTTEKGVFRSIVPSGASTGVHEALEMRD           :                                                      1one(A) : AVSKVYARSVYDSRGNPTVEVELTTEKGVFRSIVPSGASTGVHEALEMRD             __________________________________________________             __________________________________________________   1ebh(B) : GDKSKWMGKGVLHAVKNVNDVIAPAFVKANIDVKDQKAVDDFLISLDGTA           :                                                      1one(A) : GDKSKWMGKGVLHAVKNVNDVIAPAFVKANIDVKDQKAVDDFLISLDGTA             __________________________________________________             _________________________________________________1   1ebh(B) : NKSKLGANAILGVSLAASRAAAAEKNVPLYKHLADLSKSKTSPYVLPVPF           :                                                      1one(A) : NKSKLGANAILGVSLAASRAAAAEKNVPLYKHLADLSKSKTSPYVLPVPF             _________________________________________________1             52______________169_______________________________   1ebh(B) : LNVLNGGSHAGGALALQEFMIAPTGAKTFAEALRIGSEVYHNLKSLTKKR           :                                                      1one(A) : LNVLNGGSHAGGALALQEFMIAPTGAKTFAEALRIGSEVYHNLKSLTKKR             52______________169_______________________________             __________213__________226______________243_______   1ebh(B) : YGASAGNVGDEGGVAPNIQTAEEALDLIVDAIKAAGHDGKVKIGLDCASS           :                                                      1one(A) : YGASAGNVGDEGGVAPNIQTAEEALDLIVDAIKAAGHDGKVKIGLDCASS             __________213__________226______________243_______             __________________________________________________   1ebh(B) : EFFKDGKYDLDFKNPNSDKSKWLTGPQLADLYHSLMKRYPIVSIEDPFAE           :                                                      1one(A) : EFFKDGKYDLDFKNPNSDKSKWLTGPQLADLYHSLMKRYPIVSIEDPFAE             __________________________________________________             _____________________________________340__________   1ebh(B) : DDWEAWSHFFKTAGIQIVADDLTVTNPKRIATAIEKKAADALLLKVNQIG           :                                                      1one(A) : DDWEAWSHFFKTAGIQIVADDLTVTNPKRIATAIEKKAADALLLKVNQIG             _____________________________________340__________             __________________________________________________   1ebh(B) : TLSESIKAAQDSFAAGWGVMVSHRSGETEDTFIADLVVGLRTGQIKTGAP           :                                                      1one(A) : TLSESIKAAQDSFAAGWGVMVSHRSGETEDTFIADLVVGLRTGQIKTGAP             __________________________________________________             ____________________________________                 1ebh(B) : ARSERLAKLNQLLRIEEELGDNAVFAGENFHHGDKL                         :                                                      1one(A) : ARSERLAKLNQLLRIEEELGDNAVFAGENFHHGDKL                           ____________________________________

Details

Property   Value  Conformer 1 1o2d(B)  Conformer 2 1o2d(A)  Radius gyration for conformer 1 20.03 A  Radius gyration for conformer 2 20.01 A  EC Number 1.1.1.1   Click here to see the DynDom results or the famliy  Trigger ligands FE900  Trigger ligands in which conformation Conformation  2  Conformaton with trigger ligands is compact Yes  Spanning ligands Yes  Residues in enzyme contacting ligands ASP189  HIS193  HIS256  HIS270   Residues in extended bending regions contacting ligands HIS256  HIS270   Residues in extended bending regions making H-bonds or salt-bridges with ligands HIS256    Residues in extended bending regions with an H-bond between its main chain and ligands Null Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT