Erythronate-4-phosphate dehydrogenase
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 2o4c(B) : MRILADENIPVVDAFFADQGSIRRLPGRAIDRAALAEVDVLLVRSVTEVS 
         :                                                    
 2o4c(A) : MRILADENIPVVDAFFADQGSIRRLPGRAIDRAALAEVDVLLVRSVTEVS 
           __________________________________________________ 

           ____________________________________88____________ 
 2o4c(B) : RAALAGSPVRFVGTCTIGTDHLDLDYFAEAGIAWSSAPGCNARGVVDYVL 
         :                                                    
 2o4c(A) : RAALAGSPVRFVGTCTIGTDHLDLDYFAEAGIAWSSAPGCNARGVVDYVL 
           ____________________________________88____________ 

           __________________________________________________ 
 2o4c(B) : GCLLAMAEVRGADLAERTYGVVGAGQVGGRLVEVLRGLGWKVLVCDPPRQ 
         :                                                    
 2o4c(A) : GCLLAMAEVRGADLAERTYGVVGAGQVGGRLVEVLRGLGWKVLVCDPPRQ 
           __________________________________________________ 

           __________________________________________________ 
 2o4c(B) : AREPDGEFVSLERLLAEADVISLHTPLNRDGEHPTRHLLDEPRLAALRPG 
         :                                                    
 2o4c(A) : AREPDGEFVSLERLLAEADVISLHTPLNRDGEHPTRHLLDEPRLAALRPG 
           __________________________________________________ 

           __________________________________________________ 
 2o4c(B) : TWLVNASRGAVVDNQALRRLLEGGADLEVALDVWEGEPQADPELAARCLI 
         :                                                    
 2o4c(A) : TWLVNASRGAVVDNQALRRLLEGGADLEVALDVWEGEPQADPELAARCLI 
           __________________________________________________ 

           ________261_____________________285_______________ 
 2o4c(B) : ATPHIAGYSLEGKLRGTAQIYQAYCAWRGIAERVSLQDVLPETWLAGLQL 
         :                                                    
 2o4c(A) : ATPHIAGYSLEGKLRGTAQIYQAYCAWRGIAERVSLQDVLPETWLAGLQL 
           ________261_____________________285_______________ 

           __________________________________________________ 
 2o4c(B) : NPGCDPAWALATLCRAVYDPRSDDAAFRRSLTGDSATRRAAFDALRKHYP 
         :                                                    
 2o4c(A) : NPGCDPAWALATLCRAVYDPRSDDAAFRRSLTGDSATRRAAFDALRKHYP 
           __________________________________________________ 

           ______________________________                     
 2o4c(B) : PRREITGLRVATGGQAELQRVVRALGAQLV                     
         :                                                    
 2o4c(A) : PRREITGLRVATGGQAELQRVVRALGAQLV                     
           ______________________________                     

Details

  Property   Value
 Conformer 1 2o4c(B)
 Conformer 2 2o4c(A)
 Radius gyration for conformer 1 21.98 A
 Radius gyration for conformer 2 21.7 A
 EC Number 1.1.1.290  
Click here to see the DynDom results or the famliy
 Trigger ligands NAD1002
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA124  ALA206  ALA256  ARG208  ASN91  ASP146  ASP232  CYS145  GLN126  GLY123  GLY125  GLY257  HIS174  HIS183  HIS254  ILE67  PRO147  PRO148  PRO176  SER207  THR175  THR185  VAL122  VAL127  VAL233  VAL95 
 Residues in extended bending regions contacting ligands ASN91 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT