mannitol dehydrogenase
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1lj8(A) : KLNKQNLTQLAPEVKLPAYTLADTRQGIAHIGVGGFHRAHQAYYTDALnT 
         :                                                    
 1m2w(A) : KLNKQNLTQLAPEVKLPAYTLADTRQGIAHIGVGGFHRAHQAYYTDALnT 
           __________________________________________________ 

           __________________________________88______________ 
 1lj8(A) : GEGLDWSICGVGLRSEDRKARDDLAGQDYLFTLYELGDTDDTEVRVIGSI 
         :                                                    
 1m2w(A) : GEGLDWSICGVGLRSEDRKARDDLAGQDYLFTLYELGDTDDTEVRVIGSI 
           __________________________________88______________ 

           _______________________129__134________145________ 
 1lj8(A) : SDlLAEDSAQALIDKLASPEIRIVSLTITEGGYCIDDSNGEFaHLPQIQH 
         :                                                    
 1m2w(A) : SDlLAEDSAQALIDKLASPEIRIVSLTITEGGYCIDDSNGEFaHLPQIQH 
           _______________________129__134________145________ 

           ______________________________188_________________ 
 1lj8(A) : DLAHPSSPKTVFGFICAALTQRRAAGIPAFTVsCDNLPHNGAVTRKALLA 
         :                                                    
 1m2w(A) : DLAHPSSPKTVFGFICAALTQRRAAGIPAFTVsCDNLPHNGAVTRKALLA 
           ______________________________188_________________ 

           _______________________232________________________ 
 1lj8(A) : FAALHNAELHDWIKAHVSFPNAvDRITPtSTAHRLQLHDEHGIDDAWPVV 
         :                                                    
 1m2w(A) : FAALHNAELHDWIKAHVSFPNAvDRITPtSTAHRLQLHDEHGIDDAWPVV 
           _______________________232________________________ 

           _______________________283_287____________________ 
 1lj8(A) : CEPFVQWVLEDKFVNGRPAWEKVGVQFTDDVTPYEEkIGLLNGSHLALTY 
         :                                                    
 1m2w(A) : CEPFVQWVLEDKFVNGRPAWEKVGVQFTDDVTPYEEkIGLLNGSHLALTY 
           _______________________283_287____________________ 

           __________________________________________________ 
 1lj8(A) : LGFLKGYRFVHETnDPLFVAYrAYdLDVTPNLAPVPGIDLTDYKQTLVDR 
         :                                                    
 1m2w(A) : LGFLKGYRFVHETnDPLFVAYrAYdLDVTPNLAPVPGIDLTDYKQTLVDR 
           __________________________________________________ 

           __________________________________________________ 
 1lj8(A) : FSNQAIADQLERVCSDGSSKFPKFTVPTINRLIADGRETERAALVVAAWA 
         :                                                    
 1m2w(A) : FSNQAIADQLERVCSDGSSKFPKFTVPTINRLIADGRETERAALVVAAWA 
           __________________________________________________ 

           __________________________________________________ 
 1lj8(A) : LYLKGVDENGVSYTIPDPRAEFCQGLVSDDALISQRLLAVEEIFGTAIPN 
         :                                                    
 1m2w(A) : LYLKGVDENGVSYTIPDPRAEFCQGLVSDDALISQRLLAVEEIFGTAIPN 
           __________________________________________________ 

           _______________________________                    
 1lj8(A) : SPEFVAAFERCYGSLRDNGVTTTLKHLLKKP                    
         :                                                    
 1m2w(A) : SPEFVAAFERCYGSLRDNGVTTTLKHLLKKP                    
           _______________________________                    

Details

  Property   Value
 Conformer 1 1lj8(A)
 Conformer 2 1m2w(A)
 Radius gyration for conformer 1 22.66 A
 Radius gyration for conformer 2 22.78 A
 EC Number 1.1.1.67  
Click here to see the DynDom results or the famliy
 Trigger ligands MTL5600
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact No
 Spanning ligands Yes
 Residues in enzyme contacting ligands ARG231  ARG373  ASN191  ASN300  ASP230  HIS303  LEU299  LYS295  LYS381  PHE385  VAL374 
 Residues in extended bending regions contacting ligands ARG231  ASN191  ASN300  ASP230  LEU299  LYS295 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ARG231  ASN191  ASN300  ASP230  LYS295 
  Residues in extended bending regions with an H-bond between its main chain and ligands ARG231 
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT