NAGK PROTEIN
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 2ch6(D) : AAIYGGVEGGGTRSEVLLVSEDGKILAEADGLSTNHWLIGTDKCVERINE 
         :                                                    
 2ch6(B) : ****GGVEGGGTRSEVL-----------aDGLSTNH--iGTDKCVERINE 
           __________________________________________________ 

           __________________________________________________ 
 2ch6(D) : MVNRAKRKAGVDPLVPLRSLGLSLSGGDQEDAGRILIEELRDRFPYLSES 
         :                                                    
 2ch6(B) : M--------gVDPLVPLRSLGLSLSGG--eDAGRILIEELRDRFPYLSES 
           __________________________________________________ 

           ________________120_______________________________ 
 2ch6(D) : YLITTDAAGSIATATPDGGVVLISGTGSNCRLINPDGSESGCGGWGHMMG 
         :                                                    
 2ch6(B) : YLITTDAAGSIATATPDGGVVLISGTGSNCRLINPDGSESGCGGWGHMMG 
           ________________120_______________________________ 

           __________________________________________________ 
 2ch6(D) : DEGSAYWIAHQAVKIVFDSIDNLEAAPHDIGYVKQAMFHYFQVPDRLGIL 
         :                                                    
 2ch6(B) : DEGSAYWIAHQAVKIVFDSIDNLEAAPHDIGYVKQAMFHYFQVPDRLGIL 
           __________________________________________________ 

           __________________________________________________ 
 2ch6(D) : THLYRDFDKCRFAGFCRKIAEGAQQGDPLSRYIFRKAGEMLGRHIVAVLP 
         :                                                    
 2ch6(B) : THLYRDFDKCRFAGFCRKIAEGAQQGDPLSRYIFRKAGEMLGRHIVAVLP 
           __________________________________________________ 

           __________________________________________________ 
 2ch6(D) : EIDPVLFQGKIGLPILCVGSVWKSWELLKEGFLLALTQGREIQAQNFFSS 
         :                                                    
 2ch6(B) : EIDPVLFQGKIGLPILCVGSVWKSWELLKEGFLLALTQGREIQAQNFFSS 
           __________________________________________________ 

           __306_________________________334__________        
 2ch6(D) : FTLMKLRHSSALGGASLGARHIGHLLPMDYSANAIAFYSYTFS        
         :                                                    
 2ch6(B) : FTLMKLRHSSALGGASLGARH------mDYSANAIAFYSYTFS        
           __306_________________________334__________        

Details

  Property   Value
 Conformer 1 2ch6(D)
 Conformer 2 2ch6(B)
 Radius gyration for conformer 1 22.11 A
 Radius gyration for conformer 2 21.1 A
 EC Number 2.7.1.59  
Click here to see the DynDom results or the famliy
 Trigger ligands ADP470
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA156  ALA214  ARG14  ARG218  CYS217  GLY11  GLY12  GLY126  GLY215  GLY270  LYS274  SER271  SER275  THR127  THR13  VAL272 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT