Trichodiene synthase
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           ___________________22_____________________________ 
 1yyq(A) : ENFPTEYFLNTTVRLLEYIRYRDSNYTREERIENLHYAYNKAAHHFAQPR 
         :                                                    
 1yyq(B) : **FPTEYFLNTTVRLLEYIRYRDSNYTREERIENLHYAYNKAAHHFAQPR 
           ___________________22_____________________________ 

           __________________________________________________ 
 1yyq(A) : QQQLLKVDPKRLQASLQTIVGMVVYSWAKVSKECMADLSIHYTYTLVLDD 
         :                                                    
 1yyq(B) : QQQLLKVDPKRLQASLQTIVGMVVYSWAKVSKECMADLSIHYTYTLVLDD 
           __________________________________________________ 

           __________________________________________________ 
 1yyq(A) : SKDDPYPTMVNYFDDLQAGREQAHPWWALVNEHFPNVLRHFGPFCSLNLI 
         :                                                    
 1yyq(B) : SKDDPYPTMVNYFDDLQAGREQAHPWWALVNEHFPNVLRHFGPFCSLNLI 
           __________________________________________________ 

           __________________________________________________ 
 1yyq(A) : RSTLDFFEGCWIEQYNFGGFPGSHDYPQFLRRMNGLGHCVGASLWPKEQF 
         :                                                    
 1yyq(B) : RSTLDFFEGCWIEQYNFGGFPGSHDYPQFLRRMNGLGHCVGASLWPKEQF 
           __________________________________________________ 

           ______________________226______235________________ 
 1yyq(A) : NERSLFLEITSAIAQMENWMVWVNDLMSFYKEFDDERDQISLVKNYVVSD 
         :                                                    
 1yyq(B) : NERSLFLEITSAIAQMENWMVWVNDLMSFYKEFDDERDQISLVKNYVVSD 
           ______________________226______235________________ 

           _____________________________________________299__ 
 1yyq(A) : EISLHEALEKLTQDTLHSSKQMVAVFSDKDPQVMDTIECFMHGYVTWHLC 
         :                                                    
 1yyq(B) : EISLHEALEKLTQDTLHSSKQMVAVFSDKDPQVMDTIECFMHGYVTWHLC 
           _____________________________________________299__ 

           _____________________________333__________________ 
 1yyq(A) : DRRFRLSEIYEKVKEEKTEDAQKFCKFYEQAANVGAVSPSEWAYPPVAQL 
         :                                                    
 1yyq(B) : DRRFRLSEIYEKVKEEKTEDAQKFCKFYEQAANVGAVSPSEWAYPPVAQL 
           _____________________________333__________________ 

           ___                                                
 1yyq(A) : ANV                                                
         :                                                    
 1yyq(B) : ANV                                                
           ___                                                

Details

  Property   Value
 Conformer 1 1yyq(A)
 Conformer 2 1yyq(B)
 Radius gyration for conformer 1 20.2 A
 Radius gyration for conformer 2 19.98 A
 EC Number 4.2.3.6  
Click here to see the DynDom results or the famliy
 Trigger ligands POP700
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ARG182  ARG304  ASN225  ASP100  GLU233  LYS232  PHE305  SER229 
 Residues in extended bending regions contacting ligands ASN225  GLU233  LYS232  SER229 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands GLU233  LYS232  SER229 
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT