UDP-N-acetylglucosamine 2-epimerase
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1vgv(D) : KVLTVFGTRPEAIKaPLVHALAKDPFFEAKVCVTAQHRElDQVLKLFSIV 
         :                                                    
 1vgv(B) : KVLTVFGTRPEAIKaPLVHALAKDPFFEAKVCVTAQHRElDQVLKLFSIV 
           __________________________________________________ 

           __________________________________________________ 
 1vgv(D) : PDYDLNIqPGQGLTEITCRILEGLKPILAEFKPDVVLVHGDTTTTLATSL 
         :                                                    
 1vgv(B) : PDYDLNIq---GLTEITCRILEGLKPILAEFKPDVVLVHGDTTTTLATSL 
           __________________________________________________ 

           __________________________________________________ 
 1vgv(D) : AAFYQRIPVGHVEAGLRTGDLYSPWPEEANRTLTGHLAyHFSPTETSRQN 
         :                                                    
 1vgv(B) : AAFYQRIPVGHVEAGLRTGDLYSPWPEEANRTLTGHLAyHFSPTETSRQN 
           __________________________________________________ 

           ______________________180_________________________ 
 1vgv(D) : LLRENVADSRIFITGNTVIDALLWVRDQVsSDKLRSELAANYPFIDPDKK 
         :                                                    
 1vgv(B) : LLRENVADSRIFITGNTVIDALLWVRDQVsSDKLRSELAANYPFIDPDKK 
           ______________________180_________________________ 

           __________________________________________________ 
 1vgv(D) : iLVTGHRRESFGRGFEEICHALADIATTHQDIQIVYPVHLNPNVREPVNR 
         :                                                    
 1vgv(B) : iLVTGHRRESFGRGFEEICHALADIATTHQDIQIVYPVHLNPNVREPVNR 
           __________________________________________________ 

           __________________________________________________ 
 1vgv(D) : ILGHVKNVILIDPQEYLPFVWLnHAWLILTDSGGIQEEAPSLGKPVLVrD 
         :                                                    
 1vgv(B) : ILGHVKNVILIDPQEYLPFVWLnHAWLILTDSGGIQEEAPSLGKPVLVrD 
           __________________________________________________ 

           __________________________________________355_____ 
 1vgv(D) : TTERPEAVTAGTVRLVGTDKQRIVEEVTRLLKDENEYQAsRAHNPYGDGQ 
         :                                                    
 1vgv(B) : TTERPEAVTAGTVRLVGTDKQRIVEEVTRLLKDENEYQAsRAHNPYGDGQ 
           __________________________________________355_____ 

           ________________                                   
 1vgv(D) : ACSRILEALKNNRI**                                   
         :                                                    
 1vgv(B) : ACSRILEALKNNRISL                                   
           ________________                                   

Details

  Property   Value
 Conformer 1 1vgv(D)
 Conformer 2 1vgv(B)
 Radius gyration for conformer 1 21.86 A
 Radius gyration for conformer 2 21.11 A
 EC Number 5.1.3.14  
Click here to see the DynDom results or the famliy
 Trigger ligands UD21
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ARG10  ARG135  ARG313  ASP95  GLN271  GLU117  GLU12  GLU131  GLU296  GLY291  GLY292  HIS213  HIS93  ILE14  LYS15  PHE276  PRO11  SER290  THR211  THR9  THR96  TYR273 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT