sulfate adenylyltransferase
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1i2d(C) : *ANAPHGGVLKDLLARDAPRQAELAAEAESLPAVTLTERQLCDLELIMNG 
         :                                                    
 1m8p(A) : MANAPHGGVLKDLLARDAPRQAELAAEAESLPAVTLTERQLCDLELIMNG 
           __________________________________________________ 

           __________________________________________________ 
 1i2d(C) : GFSPLEGFMNQADYDRVCEDNRLADGNVFSMPITLDASQEVIDEKKLQAG 
         :                                                    
 1m8p(A) : GFSPLEGFMNQADYDRVCEDNRLADGNVFSMPITLDASQEVIDEKKLQAA 
           __________________________________________________ 

           __________________________________________________ 
 1i2d(C) : SRITLRDFRDDRNLAILTIDDIYRPDKTKEAKLVFGGDPEHPAIVYLNNT 
         :                                                    
 1m8p(A) : SRITLRDFRDDRNLAILTIDDIYRPDKTKEAKLVFGGDPEHPAIVYLNNT 
           __________________________________________________ 

           __________________________________________________ 
 1i2d(C) : VKEFYIGGKIEAVNKLNHYDYVALRYTPAELRVHFDKLGWSRVVAFQTRN 
         :                                                    
 1m8p(A) : VKEFYIGGKIEAVNKLNHYDYVALRYTPAELRVHFDKLGWSRVVAFQTRN 
           __________________________________________________ 

           _______________________226____________241_________ 
 1i2d(C) : PMHRAHRELTVRAARSRQANVLIHPVVGLTKPGDIDHFTRVRAYQALLPR 
         :                                                    
 1m8p(A) : PMHRAHRELTVRAARSRQANVLIHPVVGLTKPGDIDHFTRVRAYQALLPR 
           _______________________226____________241_________ 

           __________________________________________________ 
 1i2d(C) : YPNGMAVLGLLGLAMRMGGPREAIWHAIIRKNHGATHFIVGRDHAGPGSN 
         :                                                    
 1m8p(A) : YPNGMAVLGLLGLAMRMGGPREAIWHAIIRKNHGATHFIVGRDHAGPGSN 
           __________________________________________________ 

           __________________________________________________ 
 1i2d(C) : SKGEDFYGPYDAQHAVEKYKDELGIEVVEFQMVTYLPDTDEYRPVDQVPA 
         :                                                    
 1m8p(A) : SKGEDFYGPYDAQHAVEKYKDELGIEVVEFQMVTYLPDTDEYRPVDQVPA 
           __________________________________________________ 

           _________________________________386______________ 
 1i2d(C) : GVKTLNISGTELRRRLRSGAHIPEWFSYPEVVKILRESNPPRATQGFTIF 
         :                                                    
 1m8p(A) : GVKTLNISGTELRRRLRSGAHIPEWFSYPEVVKILRESNPPRATQGFTIF 
           _________________________________386______________ 

           __________________________________________________ 
 1i2d(C) : LTGYMNSGKDAIARALQVTLNQQGGRSVSLLLGDTVRHELSSELGFTRED 
         :                                                    
 1m8p(A) : LTGYMNSGKDAIARALQVTLNQQGGRSVSLLLGDTVRHELSSELGFTRED 
           __________________________________________________ 

           __________________________________________________ 
 1i2d(C) : RHTNIQRIAFVATELTRAGAAVIAAPIAPYEESRKFARDAVSQAGSFFLV 
         :                                                    
 1m8p(A) : RHTNIQRIAFVATELTRAGAAVIAAPIAPYEESRKFARDAVSQAGSFFLV 
           __________________________________________________ 

           __________________________________________________ 
 1i2d(C) : HVATPLEHCEQSDKRGIYAAARRGEIKGFTGVDDPYETPEKADLVVDFSK 
         :                                                    
 1m8p(A) : HVATPLEHCEQSDKRGIYAAARRGEIKGFTGVDDPYETPEKADLVVDFSK 
           __________________________________________________ 

           _______________________                            
 1i2d(C) : QSVRSIVHEIILVLESQGFLERQ                            
         :                                                    
 1m8p(A) : QSVRSIVHEIILVLESQGFLERQ                            
           _______________________                            

Details

  Property   Value
 Conformer 1 1i2d(C)
 Conformer 2 1m8p(A)
 Radius gyration for conformer 1 28.11 A
 Radius gyration for conformer 2 30.12 A
 EC Number 2.7.7.4  
Click here to see the DynDom results or the famliy
 Trigger ligands ADX578
ADX579
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands No
 Residues in enzyme contacting ligands ALA295  ALA478  ARG199  ARG292  ARG437  ARG451  ASN200  ASN454  ASP434  GLN197  GLN331  GLY291  GLY433  GLY528  HIS206  HIS294  ILE289  ILE477  ILE517  LEU209  LYS527  MET332  MET405  PHE196  PHE446  PHE529  PRO476  PRO479  THR198  THR530  VAL333 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT