Dephospho-CoA kinase
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________43______ 
 1vhl(A) : SLRYIVALTGGIGSGKSTVANAFADLGINVIDADIIARQVVEPGAPALHA 
         :                                                    
 1n3b(B) : **RYIVALTGGIGSGKSTVANAFADLGINVIDADIIARQVVEPGAPALHA 
           __________________________________________43______ 

           ____________________________________87____________ 
 1vhl(A) : IADHFGANMIAADGTLQRRALRERIFANPEEKNWLNALLHPLIQQETQHQ 
         :                                                    
 1n3b(B) : IADHFGAN-iAADGTLQRRALRERIFANPEEKNWLNALLHPLIQQETQHQ 
           ____________________________________87____________ 

           __________________________________________________ 
 1vhl(A) : IQQATSPYVLWVVPLLVENSLYKKANRVLVVDVSPETQLKRTMQRDDVTR 
         :                                                    
 1n3b(B) : IQQATSPYVLWVVPLLVENSLYKKANRVLVVDVSPETQLKRT-qRDDVTR 
           __________________________________________________ 

           __________________________________________________ 
 1vhl(A) : EHVEQILAAQATREARLAVADDVIDNNGAPDAIASDVARLHAHYLQLASQ 
         :                                                    
 1n3b(B) : EHVEQILAAQATREARLAVADDVIDNNGAPDAIASDVARLHAHYLQLASQ 
           __________________________________________________ 

           ________                                           
 1vhl(A) : FVSQEKPE                                           
         :                                                    
 1n3b(B) : FVSQEKP*                                           
           ________                                           

Details

  Property   Value
 Conformer 1 1vhl(A)
 Conformer 2 1n3b(B)
 Radius gyration for conformer 1 18.79 A
 Radius gyration for conformer 2 18.73 A
 EC Number 2.7.1.24  
Click here to see the DynDom results or the famliy
 Trigger ligands ADP1
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact No
 Spanning ligands No
 Residues in enzyme contacting ligands ALA178  ARG140  ARG144  ASN175  GLY10  GLY12  GLY14  GLY177  ILE11  LYS15  PRO179  SER13  SER16  THR17 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT