Glycerol dehydrogenase
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1jq5(A) : AAERVFISPAKYVQGKNVITKIANYLEGIGNKTVVIADEIVWKIAGHTIV 
         :                                                    
 1jpu(A) : *AERVFISPAKYVQGKNVITKIANYLEGIGNKTVVIADEIVWKIAGHTIV 
           __________________________________________________ 

           __________________________________________________ 
 1jq5(A) : NELKKGNIAAEEVVFSGEASRNEVERIANIARKAEAAIVIGVGGGKTLDT 
         :                                                    
 1jpu(A) : NELKKGNIAAEEVVFSGEASRNEVERIANIARKAEAAIVIGVGGGKTLDT 
           __________________________________________________ 

           ___________________123_______________________149__ 
 1jq5(A) : AKAVADELDAYIVIVPTAASTDAPTSALSVIYSDDGVFESYRFYKKNPDL 
         :                                                    
 1jpu(A) : AKAVADELDAYIVIVPTAASTDAPTSALSV-----gVFESYRFYKKNPDL 
           ___________________123_______________________149__ 

           __________________________________________________ 
 1jq5(A) : VLVDTKIIANAPPRLLASGIADALATWVEARSVIKSGGKTMAGGIPTIAA 
         :                                                    
 1jpu(A) : VLVDTKIIANAPPRLLASGIADALATWVEARSVIKSGGKTMAGGIPTIAA 
           __________________________________________________ 

           __________________________________________________ 
 1jq5(A) : EAIAEKCEQTLFKYGKLAYESVKAKVVTPALEAVVEANTLLSGLGFESGG 
         :                                                    
 1jpu(A) : EAIAEKCEQTLFKYGKLAYESVKAKVVTPALEAVVEANTLLSGLGFESGG 
           __________________________________________________ 

           __________________________________________________ 
 1jq5(A) : LAAAHAIHNGFTALEGEIHHLTHGEKVAFGTLVQLALEEHSQQEIERYIE 
         :                                                    
 1jpu(A) : LAAAHAIHNGFTALEGEIHHLTHGEKVAFGTLVQLALEEHSQQEIERYIE 
           __________________________________________________ 

           __________________________________________________ 
 1jq5(A) : LYLCLDLPVTLEDIKLKDASREDILKVAKAATAEGETIHNAFNVTADDVA 
         :                                                    
 1jpu(A) : LYLCLDLPVTLEDIKLKDASREDILKVAKAATAEGETIHNAFNVTADDVA 
           __________________________________________________ 

           _________________                                  
 1jq5(A) : DAIFAADQYAKAYKEK*                                  
         :                                                    
 1jpu(A) : DAIFAADQYAKAYKEKH                                  
           _________________                                  

Details

  Property   Value
 Conformer 1 1jq5(A)
 Conformer 2 1jpu(A)
 Radius gyration for conformer 1 20.37 A
 Radius gyration for conformer 2 20.5 A
 EC Number 1.1.1.6  
Click here to see the DynDom results or the famliy
 Trigger ligands NAD401
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA124  ALA162  ASP100  ASP123  ASP173  ASP39  GLY95  GLY96  HIS274  ILE41  ILE45  LEU129  LEU166  LYS103  LYS97  PHE247  PRO163  SER121  SER127  SER130  THR118  THR122  TYR133  VAL131  VAL42 
 Residues in extended bending regions contacting ligands ALA124  ASP123  SER121  SER127  THR122 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands SER121  SER127 
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT