Orotidine 5'-phosphate decarboxylase
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           _________________________27_____________42_____49_ 
 2cze(A) : MIVLALDVYEGERAIKIAKSVKDYISMIKVNWPLILGSGVDIIRRLKEET 
         :                                                    
 2czd(B) : MIVLALDVYEGERAIKIAKSVKDYISMIKVNWPLILGSGVDIIRRLKEET 
           _________________________27_____________42_____49_ 

           __________________________________________________ 
 2cze(A) : GVEIIADLKLADIPNTNRLIARKVFGAGADYVIVHTFVGRDSVMAVKELG 
         :                                                    
 2czd(B) : GVEIIADLKLADIPNTNRLIARKVFGAGADYVIVHTFVGRDSVMAVKELG 
           __________________________________________________ 

           __________________________________________________ 
 2cze(A) : EIIMVVEMSHPGALEFINPLTDRFIEVANEIEPFGVIAPGTRPERIGYIR 
         :                                                    
 2czd(B) : EIIMVVEMSHPGALEFINPLTDRFIEVANEIEPFGVIAPGTRPERIGYIR 
           __________________________________________________ 

           ____157___________________________________________ 
 2cze(A) : DRLKEGIKILAPGIGAQGGKAKDAVKAGADYIIVGRAIYNAPNPREAAKA 
         :                                                    
 2czd(B) : DRLKEGIKILAPGIGAQGGKAKDAVKAGADYIIVGRAIYNAPNPREAAKA 
           ____157___________________________________________ 

           ________                                           
 2cze(A) : IYDEIRGV                                           
         :                                                    
 2czd(B) : IYDEIRG*                                           
           ________                                           

Details

  Property   Value
 Conformer 1 2cze(A)
 Conformer 2 2czd(B)
 Radius gyration for conformer 1 16.53 A
 Radius gyration for conformer 2 16.76 A
 EC Number 4.1.1.23  
Click here to see the DynDom results or the famliy
 Trigger ligands U5P401
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA5  ARG186  ASN31  ASP57  ASP7  GLN167  GLY185  ILE137  ILE164  LYS29  LYS59  MET108  PRO162  SER109  VAL184 
 Residues in extended bending regions contacting ligands ASN31  ASP57  GLN167  ILE164  LYS29  PRO162 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ASN31  GLN167  ILE164  LYS29 
  Residues in extended bending regions with an H-bond between its main chain and ligands ILE164 
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT