Probable butyrate kinase 2
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1saz(A) : *FRILTINPGSTSTKLSIFEDER-vK-qNFSHSPDELGRFQKILDQLEFR 
         :                                                    
 1x9j(D) : MFRILTINPGSTSTKLSIFEDERMVKMQNFSHSPDELGRFQKILDQLEFR 
           __________________________________________________ 

           __________________________________________________ 
 1saz(A) : EKIARQFVEETGYSLSSFSAFVSRGGLLDPIPGGVYLVDGL-iKTLKSGK 
         :                                                    
 1x9j(D) : EKIARQFVEETGYSLSSFSAFVSRGGLLDPIPGGVYLVDGLMIKTLKSGK 
           __________________________________________________ 

           ____________________________131________________150 
 1saz(A) : NGEHASNLGAIIAHRFSSETGVPAYVVDPVVVDE-eDVARVSGHPNYQRK 
         :                                                    
 1x9j(D) : NGEHASNLGAIIAHRFSSETGVPAYVVDPVVVDEMEDVARVSGHPNYQRK 
           ____________________________131________________150 

           _154______________________________________________ 
 1saz(A) : SIFHALNQKTVAKEVAR--nKRYEE-nLVVAH-gGGISIAAHRKGRVIDV 
         :                                                    
 1x9j(D) : SIFHALNQKTVAKEVARMMNKRYEEMNLVVAHMGGGISIAAHRKGRVIDV 
           _154______________________________________________ 

           __________________________________________________ 
 1saz(A) : NNALDGDGPFTPERSGTLPLTQLVDLCFSGKFTYEE-kKRIVGNGGLVAY 
         :                                                    
 1x9j(D) : NNALDGDGPFTPERSGTLPLTQLVDLCFSGKFTYEEMKKRIVGNGGLVAY 
           __________________________________________________ 

           __________________________________________________ 
 1saz(A) : LGTSDAREVVRRIKQGDEWAKRVYRA-aYQIAKWIGK-aAVLKGEVDFIV 
         :                                                    
 1x9j(D) : LGTSDAREVVRRIKQGDEWAKRVYRAMAYQIAKWIGKMAAVLKGEVDFIV 
           __________________________________________________ 

           _______________________________334________________ 
 1saz(A) : LTGGLAHEKEFLVPWITKRVSFIAPVLVFPGSNEEKALALSALRVLRGEE 
         :                                                    
 1x9j(D) : LTGGLAHEKEFLVPWITKRVSFIAPVLVFPGSNEEKALALSALRVLRGEE 
           _______________________________334________________ 

           _________________________                          
 1saz(A) : KPKNYSEESRRWRERYDSYLDGILR                          
         :                                                    
 1x9j(D) : KPKNYSEESRRWRERYDSYLDGI**                          
           _________________________                          

Details

  Property   Value
 Conformer 1 1saz(A)
 Conformer 2 1x9j(D)
 Radius gyration for conformer 1 21.45 A
 Radius gyration for conformer 2 20.88 A
 EC Number 2.7.2.7  
Click here to see the DynDom results or the famliy
 Trigger ligands ACP399
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact No
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA256  ARG214  ARG257  ASP255  GLU308  GLY184  GLY185  GLY186  GLY304  HIS154  HIS182  HIS307  LEU305  SER254 
 Residues in extended bending regions contacting ligands HIS154 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands HIS154 
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT