tRNA (Guanine-N(1)-)-methyltransferase
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1uaj(A) : GLVPRGSHMWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFT 
         :                                                    
 1ual(A) : ******SHMWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFT 
           __________________________________________________ 

           __________________________________________________ 
 1uaj(A) : FDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGR 
         :                                                    
 1ual(A) : FDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGR 
           __________________________________________________ 

           __________________________________________________ 
 1uaj(A) : KLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGE 
         :                                                    
 1ual(A) : KLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGE 
           __________________________________________________ 

           _____________________175__________________________ 
 1uaj(A) : LPAMTLIDAVARFIPGVL----gLLDCPHYTRPEVLEGLTVPPVLMSGHH 
         :                                                    
 1ual(A) : LPAMTLIDAVARFIPGVLsFADGLLDCPHYTRPEVLEGLTVPPVLMSGHH 
           _____________________175__________________________ 

           _________________________________________________  
 1uaj(A) : EEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEAQAEHNS****  
         :                                                    
 1ual(A) : EEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEAQAEHNSLEHH  
           _________________________________________________  

Details

  Property   Value
 Conformer 1 1uaj(A)
 Conformer 2 1ual(A)
 Radius gyration for conformer 1 23.27 A
 Radius gyration for conformer 2 23.37 A
 EC Number 2.1.1.31  
Click here to see the DynDom results or the famliy
 Trigger ligands SAH301
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact No
 Spanning ligands No
 Residues in enzyme contacting ligands GLN90  GLU116  GLY113  GLY134  GLY140  GLY141  ILE133  LEU138  LEU87  PRO144  PRO89  SER132  SER88  THR139  TRP131  TYR115  TYR136  TYR86  VAL137 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT