UDP-N-ACETYLMURAMOYL-L-ALANINE
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1eeh(A) : ADYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLDKLPEAV 
         :                                                    
 1e0d(A) : ADYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLDKLPEAV 
           __________________________________________________ 

           __________________________________________________ 
 1eeh(A) : ERHTGSLNDEWLMAADLIVASPGIALAHPSLSAAADAGIEIVGDIELFCR 
         :                                                    
 1e0d(A) : ERHTGSLNDEWLMAADLIVASPGIALAHPSLSAAADAGIEIVGDIELFCR 
           __________________________________________________ 

           __________________________________________________ 
 1eeh(A) : EAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLDDE 
         :                                                    
 1e0d(A) : EAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLDDE 
           __________________________________________________ 

           __________________________________________________ 
 1eeh(A) : CELYVLELSSFQLETTSSLQAVAATILNVTEDHMDRYPFGLQQYRAAKLR 
         :                                                    
 1e0d(A) : CELYVLELSSFQLETTSSLQAVAATILNVTED------fGLQQYRAAKLR 
           __________________________________________________ 

           __________________________________________________ 
 1eeh(A) : IYENAKVCVVNADDALTMPIRGADERCVSFGVNMGDYHL------tWLRV 
         :                                                    
 1e0d(A) : IYENAKVCVVNADDALTMPI--aDERCVSFGVNMGDYHLNHQQGETWLRV 
           __________________________________________________ 

           ___________________________________________296____ 
 1eeh(A) : KGEKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLP 
         :                                                    
 1e0d(A) : KGEKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLP 
           ___________________________________________296____ 

           __________________________________________________ 
 1eeh(A) : HRFEVVLEHNGVRWINDSKATNVGSTEAALNGLHVDGTLHLLLGGDGKSA 
         :                                                    
 1e0d(A) : HRFEVVLEHNGVRWINDSKATNVGSTEAALNGLHVDGTLHLLLGGDGKSA 
           __________________________________________________ 

           __________________________________________________ 
 1eeh(A) : DFSPLARYLNGDNVRLYCFGRDGAQLAALRPEVAEQTETMEQAMRLLAPR 
         :                                                    
 1e0d(A) : DFSPLARYLNGDNVRLYCFGRDGAQLAALRPEVAEQTETMEQAMRLLAPR 
           __________________________________________________ 

           _____________________________________              
 1eeh(A) : VQPGDMVLLSPACASLDQFKNFEQRGNEFARLAKELG              
         :                                                    
 1e0d(A) : VQPGDMVLLSPACASLDQFKNFEQRGNEFARLAKELG              
           _____________________________________              

Details

  Property   Value
 Conformer 1 1eeh(A)
 Conformer 2 1e0d(A)
 Radius gyration for conformer 1 22.99 A
 Radius gyration for conformer 2 23.93 A
 EC Number 6.3.2.9  
Click here to see the DynDom results or the famliy
 Trigger ligands UMA450
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands No
 Residues in enzyme contacting ligands ARG37  ASN138  ASP35  GLN162  GLY12  GLY137  GLY14  GLY140  GLY73  HIS183  ILE11  LEU15  PHE161  PRO142  PRO72  SER159  SER71  THR16  THR36 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT