Xanthine phosphoribosyltransferase
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1y0b(A) : NAeALKRKIEEEGVVLSDQVLKVDSFLNHQIDPLL-qRIGDEFASRFAKD 
         :                                                    
 2fxv(A) : *MEALKRKIEEEGVVLSDQVLKVDSFLNHQIDPLLMQRIGDEFASRFAKD 
           __________________________________________________ 

           __________________________77______________________ 
 1y0b(A) : GITKIVTIESSGIAPAV-tGLKLGVPVVFARKHKSLTLTDNLLTASVYSF 
         :                                                    
 2fxv(A) : GITKIVTIESSGIAPAVMTGLKLGVPVVFARKHKSLTLTDNLLTASVYSF 
           __________________________77______________________ 

           _____107__________________________________________ 
 1y0b(A) : TKQTESQIAVSGTHLSDQDHVLIIDDFLANGQAAHGLVSIVKQAGASIAG 
         :                                                    
 2fxv(A) : TKQTESQIAVSGTHLSDQDHVLIIDDFLANGQAAHGLVSIVKQAGASIAG 
           _____107__________________________________________ 

           __________________________________________         
 1y0b(A) : IGIVIEKSFQPGRDELVKLGYRVESLARIQSLEEGKVSFVQE         
         :                                                    
 2fxv(A) : IGIVIEKSFQPGRDELVKLGYRVESLARIQSLEEGKVSFVQ*         
           __________________________________________         

Details

  Property   Value
 Conformer 1 1y0b(A)
 Conformer 2 2fxv(A)
 Radius gyration for conformer 1 16.34 A
 Radius gyration for conformer 2 16.35 A
 EC Number 2.4.2.22  
Click here to see the DynDom results or the famliy
 Trigger ligands 5GP200
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact No
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA128  ALA132  ASN129  ASN27  ASP124  ASP125  GLN131  GLY130  LEU127  LEU20  LYS156  PHE126  PHE99  THR100  VAL19 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT