aspartate aminotransferase
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           ________9_______________________34________________ 
 1j32(A) : MKLAARVESVSPSMTLIIDAKAKAMKAEGIDVCSFSAGEPDFNTPKHIVE 
         :                                                    
 1j32(B) : MKLAARVESVSPSMTLIIDAKAKAMKAEGIDVCSFSAGEPDFNTPKHIVE 
           ________9_______________________34________________ 

           __________________________________________________ 
 1j32(A) : AAKAALEQGKTRYGPAAGEPRLREAIAQKLQRDNGLCYGADNILVTNGGK 
         :                                                    
 1j32(B) : AAKAALEQGKTRYGPAAGEPRLREAIAQKLQRDNGLCYGADNILVTNGGK 
           __________________________________________________ 

           __________________________________________________ 
 1j32(A) : QSIFNLMLAMIEPGDEVIIPAPFWVSYPEMVKLAEGTPVILPTTVETQFK 
         :                                                    
 1j32(B) : QSIFNLMLAMIEPGDEVIIPAPFWVSYPEMVKLAEGTPVILPTTVETQFK 
           __________________________________________________ 

           __________________________________________________ 
 1j32(A) : VSPEQIRQAITPKTKLLVFNTPSNPTGMVYTPDEVRAIAQVAVEAGLWVL 
         :                                                    
 1j32(B) : VSPEQIRQAITPKTKLLVFNTPSNPTGMVYTPDEVRAIAQVAVEAGLWVL 
           __________________________________________________ 

           __________________________________________________ 
 1j32(A) : SDEIYEKILYDDAQHLSIGAASPEAYERSVVCSGFAKTYAMTGWRVGFLA 
         :                                                    
 1j32(B) : SDEIYEKILYDDAQHLSIGAASPEAYERSVVCSGFAKTYAMTGWRVGFLA 
           __________________________________________________ 

           __________________________________________________ 
 1j32(A) : GPVPLVKAATKIQGHSTSNVCTFAQYGAIAAYENSQDCVQEMLAAFAERR 
         :                                                    
 1j32(B) : GPVPLVKAATKIQGHSTSNVCTFAQYGAIAAYENSQDCVQEMLAAFAERR 
           __________________________________________________ 

           ___________________________________338____________ 
 1j32(A) : RYMLDALNAMPGLECPKPDGAFYMFPSIAKTGRSSLDFCSELLDQHQVAT 
         :                                                    
 1j32(B) : RYMLDALNAMPGLECPKPDGAFYMFPSIAKTGRSSLDFCSELLDQHQVAT 
           ___________________________________338____________ 

           353___359___365_______________________             
 1j32(A) : VPGAAFGADDCIRLSYATDLDTIKRGMERLEKFLHGIL             
         :                                                    
 1j32(B) : VPGAAFGADDCIRLSYATDLDTIKRGMERLEKFLHGIL             
           353___359___365_______________________             

Details

  Property   Value
 Conformer 1 1j32(A)
 Conformer 2 1j32(B)
 Radius gyration for conformer 1 20.89 A
 Radius gyration for conformer 2 21.04 A
 EC Number 2.6.1.1  
Click here to see the DynDom results or the famliy
 Trigger ligands PLP413
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands No
 Residues in enzyme contacting ligands TYR63 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT