CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1kph(D) : DELKPHFANVQAHYDLSDDFFRLFLDPTQTYSCAYFERDDMTLQEAQIAK 
         :                                                    
 1kp9(B) : ***************LSDDFFRLFLDPTQTYSCAYFERDDMTLQEAQIAK 
           __________________________________________________ 

           __________________________________________________ 
 1kph(D) : IDLALGKLGLQPGMTLLDVGCGWGATMMRAVEKYDVNVVGLTLSKNQANH 
         :                                                    
 1kp9(B) : IDLALGKLGLQPGMTLLDVGCGWGATMMRAVEKYDVNVVGLTLSKNQANH 
           __________________________________________________ 

           __________________________________________________ 
 1kph(D) : VQQLVANSENLRSKRVLLAGWEQFDEPVDRIVSIGAFEHFGHERYDAFFS 
         :                                                    
 1kp9(B) : VQQLVANSENLRSKRVLLAGWEQFDEPVDRIVSIGAFEHFGHERYDAFFS 
           __________________________________________________ 

           ________________171__________________________200__ 
 1kph(D) : LAHRLLPADGVMLLHTITGLHPKEIHERGLPMSFTFARFLKFIVTEIFPG 
         :                                                    
 1kp9(B) : LAHRLLPADGVMLLHTITGLHPKEIHERGLPMSFTFARFLKFIVTEIFPG 
           ________________171__________________________200__ 

           __________________________________________________ 
 1kph(D) : GRLPSIPMVQECASANGFTVTRVQSLQPHYAKTLDLWSAALQANKGQAIA 
         :                                                    
 1kp9(B) : GRLPSIPMVQECASANGFTVTRVQSLQPHYAKTLDLWSAALQANKGQAIA 
           __________________________________________________ 

           ___________________________________                
 1kph(D) : LQSEEVYERYMKYLTGCAEMFRIGYIDVNQFTCQK                
         :                                                    
 1kp9(B) : LQSEEVYERYMKYLTGCAEMFRIGYIDVNQFTCQK                
           ___________________________________                

Details

  Property   Value
 Conformer 1 1kph(D)
 Conformer 2 1kp9(B)
 Radius gyration for conformer 1 18.39 A
 Radius gyration for conformer 2 18.78 A
 EC Number 2.1.1.79  
Click here to see the DynDom results or the famliy
 Trigger ligands SAH4900
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands No
 Residues in enzyme contacting ligands ALA121  ALA138  CYS73  GLN99  GLU124  GLY122  GLY137  GLY72  GLY74  HIS141  ILE136  LEU93  LEU95  PHE142  SER34  SER96  THR32  THR94  TRP123  TYR16  TYR33  VAL12 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT