glucokinase isoform 2
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           _______________________________________________62_ 
 1v4s(A) : TLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVR 
         :                                                    
 1v4t(A) : *MVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVR 
           _______________________________________________62_ 

           ____________________________93____________________ 
 1v4s(A) : STPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPED 
         :                                                    
 1v4t(A) : STPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPED 
           ____________________________93____________________ 

           __________________________________________________ 
 1v4s(A) : AMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGI 
         :                                                    
 1v4t(A) : AMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRH------- 
           __________________________________________________ 

           ________________________________198_______________ 
 1v4s(A) : LLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISC 
         :                                                    
 1v4t(A) : ----------------nVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISC 
           ________________________________198_______________ 

           __________________________________________________ 
 1v4s(A) : YYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDS 
         :                                                    
 1v4t(A) : YYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDS 
           __________________________________________________ 

           __________________________________________________ 
 1v4s(A) : GELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDEN 
         :                                                    
 1v4t(A) : GELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDEN 
           __________________________________________________ 

           __________________________________________________ 
 1v4s(A) : LLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTD 
         :                                                    
 1v4t(A) : LLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTD 
           __________________________________________________ 

           __________________________________________________ 
 1v4s(A) : CDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVY 
         :                                                    
 1v4t(A) : CDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVY 
           __________________________________________________ 

           ________________________________________________   
 1v4s(A) : KLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKAC   
         :                                                    
 1v4t(A) : KLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKAC   
           ________________________________________________   

Details

  Property   Value
 Conformer 1 1v4s(A)
 Conformer 2 1v4t(A)
 Radius gyration for conformer 1 22.75 A
 Radius gyration for conformer 2 24.65 A
 EC Number 2.7.1.1  
Click here to see the DynDom results or the famliy
 Trigger ligands AGC500
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ASN204  ASN231  ASP205  CYS230  GLN287  GLU256  GLU290  GLY229  ILE225  LYS169  PHE152  PRO153  SER151  THR168 
 Residues in extended bending regions contacting ligands ASN204  ASP205 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ASN204  ASP205 
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT