Inositol monophosphatase 2
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 2czh(A) : PWEECFQAAVQLALRAGQIIRKALTEEKdLVTETDHLVEDLIISELRERF 
         :                                                    
 2czk(A) : PWEECFQAAVQLALRAGQIIRKALTEE-dLVTETDHLVEDLIISELRERF 
           __________________________________________________ 

           __________________________________________________ 
 2czh(A) : PSHRFIAEEAAASGAKCVLTHSPTWIIDPIDGTCNFVHRFPTVAVSIGFA 
         :                                                    
 2czk(A) : PSHRFIAE------aKCVLTHSPTWIIDPIDGTCNFVHRFPTVAVSIGFA 
           __________________________________________________ 

           _______________________________________165___171__ 
 2czh(A) : VRQELEFGVIYHCTEERLYTGRRGRGAFCNGQRLRVSGETDLSKALVLTE 
         :                                                    
 2czk(A) : VRQELEFGVIYHCTEERLYTGRRGRGAFCNGQRLRVSGETDLSKALVLTE 
           _______________________________________165___171__ 

           __________________194___200_______________________ 
 2czh(A) : IGPKRDPATLKLFLSNMERLLHAKAHGVRVIGSSTLALCHLASGAADAYY 
         :                                                    
 2czk(A) : IGPKRDPATLKLFLSNMERLLHAKAHGVRVIGSSTLALCHLASGAADAYY 
           __________________194___200_______________________ 

           __________________________________________________ 
 2czh(A) : QFGLHCWDLAAATVIIREAGGIVIDTSGGPLDLMACRVVAASTREMAMLI 
         :                                                    
 2czk(A) : QFGLHCWDLAAATVIIREAGGIVIDTSGGPLDLMACRVVAASTREMAMLI 
           __________________________________________________ 

           __________                                         
 2czh(A) : AQAL******                                         
         :                                                    
 2czk(A) : AQALQTINYG                                         
           __________                                         

Details

  Property   Value
 Conformer 1 2czh(A)
 Conformer 2 2czk(A)
 Radius gyration for conformer 1 17.58 A
 Radius gyration for conformer 2 17.73 A
 EC Number 3.1.3.25  
Click here to see the DynDom results or the famliy
 Trigger ligands PO4101
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ASP104  GLN224  ILE174  SER206  SER207 
 Residues in extended bending regions contacting ligands ILE174 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT