DIAMINOPIMELIC ACID DEHYDROGENASE
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1f06(A) : MTNIRVAIVGYGNLGRSVEKLIAKQPDMDLVGIFSRRATLDTKTPVFDVA 
         :                                                    
 1f06(B) : MTNIRVAIVGYGNLGRSVEKLIAKQPDMDLVGIFSRRATLDTKTPVFDVA 
           __________________________________________________ 

           __________________________________________________ 
 1f06(A) : DVDKHADDVDVLFLCMGSATDIPEQAPKFAQFACTVDTYDNHRDIPRHRQ 
         :                                                    
 1f06(B) : DVDKHADDVDVLFLCMGSATDIPEQAPKFAQFACTVDTYDNHRDIPRHRQ 
           __________________________________________________ 

           ______________________________________141_________ 
 1f06(A) : VMNEAATAAGNVALVSTGWDPGMFSINRVYAAAVLAEHQQHTFWGPGLSQ 
         :                                                    
 1f06(B) : VMNEAATAAGNVALVSTGWDPGMFSINRVYAAAVLAEHQQHTFWGPGLSQ 
           ______________________________________641_________ 

           _________________170______________________________ 
 1f06(A) : GHSDALRRIPGVQKAVQYTLPSEDALEKARRGEAGDLTGKQTHKRQCFVV 
         :                                                    
 1f06(B) : GHSDALRRIPGVQKAVQYTLPSEDALEKARRGEAGDLTGKQTHKRQCFVV 
           _________________670______________________________ 

           ___________________________________238____________ 
 1f06(A) : ADAADHERIENDIRTMPDYFVGYEVEVNFIDEATFDSEHTGMPHGGHVIT 
         :                                                    
 1f06(B) : ADAADHERIENDIRTMPDYFVGYEVEVNFIDEATFDSEHTGMPHGGHVIT 
           ___________________________________738____________ 

           __________________________________________________ 
 1f06(A) : TGDTGGFNHTVEYILKLDRNPDFTASSQIAFGRAAHRMKQQGQSGAFTVL 
         :                                                    
 1f06(B) : TGDTGGFNHTVEYILKLDRNPDFTASSQIAFGRAAHRMKQQGQSGAFTVL 
           __________________________________________________ 

           ____________________                               
 1f06(A) : EVAPYLLSPENLDDLIARDV                               
         :                                                    
 1f06(B) : EVAPYLLSPENLDDLIARDV                               
           ____________________                               

Details

  Property   Value
 Conformer 1 1f06(A)
 Conformer 2 1f06(B)
 Radius gyration for conformer 1 21.99 A
 Radius gyration for conformer 2 20.62 A
 EC Number 1.4.1.16  
Click here to see the DynDom results or the famliy
 Trigger ligands 2NP950
NDP901
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ARG536  ARG537  ARG657  ARG695  ASN513  ASN770  ASP590  ASP620  ASP654  CYS565  GLN650  GLY510  GLY512  GLY567  GLY618  GLY651  HIS652  HIS744  LEU514  LEU648  MET566  PRO621  SER535  SER568  SER649  THR588  THR617  THR669  THR774  TRP619  TRP644  TYR511 
 Residues in extended bending regions contacting ligands HIS744  LEU648  SER649  THR669  TRP644 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands HIS744  SER649  THR669 
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT