Pyruvate kinase isozymes M1/M2
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1a49(D) : IQTQQLHAAMADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVETLK 
         :                                                    
 1aqf(H) : IQTQQLHAAMADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVETLK 
           __________________________________________________ 

           _________________________________________________1 
 1a49(D) : EMIKSGMNVARMNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVAL 
         :                                                    
 1aqf(H) : EMIKSGMNVARMNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVAL 
           __________________________________________________ 

           914_______________________________________________ 
 1a49(D) : DTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYK 
         :                                                    
 1aqf(H) : DTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYK 
           114_______________________________________________ 

           ____________________________________________2009__ 
 1a49(D) : NICKVVDVGSKVYVDDGLISLQVKQKGPDFLVTEVENGGFLGSKKGVNLP 
         :                                                    
 1aqf(H) : NICKVVDVGSKVYVDDGLISLQVKQKGPDFLVTEVENGGFLGSKKGVNLP 
           _____________________________________________209__ 

           __________________________________________________ 
 1a49(D) : GAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKILGEKG 
         :                                                    
 1aqf(H) : GAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKILGEKG 
           __________________________________________________ 

           __________________________________________________ 
 1a49(D) : KNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKM 
         :                                                    
 1aqf(H) : KNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKM 
           __________________________________________________ 

           __________________________________________________ 
 1a49(D) : IIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLS 
         :                                                    
 1aqf(H) : IIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLS 
           __________________________________________________ 

           __________________________________________________ 
 1a49(D) : GETAKGDYPLEAVRMQHLIAREAEAAMFHRKLFEELARSSSHSTDLMEAM 
         :                                                    
 1aqf(H) : GETAKGDYPLEAVRMQHLIAREAEAAMFHRKLFEELARSSSHSTDLMEAM 
           __________________________________________________ 

           __________________________________________________ 
 1a49(D) : AMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNHQTARQ 
         :                                                    
 1aqf(H) : AMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNHQTARQ 
           __________________________________________________ 

           __________________________________________________ 
 1a49(D) : AHLYRGIFPVVCKDPVQEAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVL 
         :                                                    
 1aqf(H) : AHLYRGIFPVVCKDPVQEAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVL 
           __________________________________________________ 

           ___________________                                
 1a49(D) : TGWRPGSGFTNTMRVVPVP                                
         :                                                    
 1aqf(H) : TGWRPGSGFTNTMRVVPVP                                
           ___________________                                

Details

  Property   Value
 Conformer 1 1a49(D)
 Conformer 2 1aqf(H)
 Radius gyration for conformer 1 24.06 A
 Radius gyration for conformer 2 25.16 A
 EC Number 2.7.1.40  
Click here to see the DynDom results or the famliy
 Trigger ligands ATP2335
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA2165  ARG1872  ARG1919  ASN1874  ASP1977  ASP2095  GLY1927  GLY2162  HIS1877  HIS1883  LYS2006  LYS2069  LYS2166  PRO1852  SER2161  THR1849  TYR1882 
 Residues in extended bending regions contacting ligands ARG1919  LYS2006 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ARG1919  LYS2006 
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT