RIBOKINASE
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           ________13_______________________38_______________ 
 1rka(A) : AGSLVVLGSINADHILNLQSFPTPGETVTGNHYQVAFGGKGANQAVAAGR 
         :                                                    
 1rkd    : AGSLVVLGSINADHILNLQSFPTPGETVTGNHYQVAFGGKGANQAVAAGR 
           ________13_______________________38_______________ 

           ____________67____________________________97______ 
 1rka(A) : SGANIAFIACTGDDSIGESVRQQLATDNIDITPVSVIKGESTGVALIFVN 
         :                                                    
 1rkd    : SGANIAFIACTGDDSIGESVRQQLATDNIDITPVSVIKGESTGVALIFVN 
           ____________67____________________________97______ 

           ________114_______________________________________ 
 1rka(A) : GEGENVIGIHAGANAALSPALVEAQRERIANASALLMQLESPLESVMAAA 
         :                                                    
 1rkd    : GEGENVIGIHAGANAALSPALVEAQRERIANASALLMQLESPLESVMAAA 
           ________114_______________________________________ 

           __________________________________________________ 
 1rka(A) : KIAHQNKTIVALNPAPARELPDELLALVDIITPNETEAEKLTGIRVENDE 
         :                                                    
 1rkd    : KIAHQNKTIVALNPAPARELPDELLALVDIITPNETEAEKLTGIRVENDE 
           __________________________________________________ 

           __________________________________________________ 
 1rka(A) : DAAKAAQVLHEKGIRTVLITLGSRGVWASVNGEGQRVPGFRVQAVDTIAA 
         :                                                    
 1rkd    : DAAKAAQVLHEKGIRTVLITLGSRGVWASVNGEGQRVPGFRVQAVDTIAA 
           __________________________________________________ 

           __________________________________________________ 
 1rka(A) : GDTFNGALITALLEEKPLPEAIRFAHAAAAIAVTRKGAQPSVPWREEIDA 
         :                                                    
 1rkd    : GDTFNGALITALLEEKPLPEAIRFAHAAAAIAVTRKGAQPSVPWREEIDA 
           __________________________________________________ 

           ______                                             
 1rka(A) : FLDRQ*                                             
         :                                                    
 1rkd    : FLDRQR                                             
           ______                                             

Details

  Property   Value
 Conformer 1 1rka(A)
 Conformer 2 1rkd( )
 Radius gyration for conformer 1 18.83 A
 Radius gyration for conformer 2 18.44 A
 EC Number 2.7.1.15  
Click here to see the DynDom results or the famliy
 Trigger ligands RIB311
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA98  ASN14  ASN46  ASP16  ASP255  GLU143  GLY41  GLY42  ILE100  ILE110  LYS43 
 Residues in extended bending regions contacting ligands ALA98  ASN14  ASP16  GLY41  GLY42  ILE100  LYS43 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ASN14  ASP16  GLY42  LYS43 
  Residues in extended bending regions with an H-bond between its main chain and ligands GLY42  LYS43 
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT