SERINE/THREONINE-PROTEIN KINASE CHK2
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 2cn5(A) : HMSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRnVE 
         :                                                    
 2cn8(A) : ****YPKALRDEYIMSKTLGS----eVKLAFERKTCKKVAIKIISK-nVE 
           __________________________________________________ 

           __________________________________________________ 
 2cn5(A) : TEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKE 
         :                                                    
 2cn8(A) : TEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKE 
           __________________________________________________ 

           ________________________________________________37 
 2cn5(A) : ATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGH 
         :                                                    
 2cn8(A) : ATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGH 
           ________________________________________________37 

           2____________________________403__________________ 
 2cn5(A) : SKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICL 
         :                                                    
 2cn8(A) : SKIL--tSLMRTLC--pTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICL 
           2____________________________403__________________ 

           __________________________________________________ 
 2cn5(A) : SGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDP 
         :                                                    
 2cn8(A) : SGYPPFSEH---vSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDP 
           __________________________________________________ 

           _________________________________                  
 2cn5(A) : KARFTTEEALRHPWLQDEDMKRKFQDLLSEENE                  
         :                                                    
 2cn8(A) : KARFTTEEALRHPWLQDEDMKRKFQDLLSEEN*                  
           _________________________________                  

Details

  Property   Value
 Conformer 1 2cn5(A)
 Conformer 2 2cn8(A)
 Radius gyration for conformer 1 20.64 A
 Radius gyration for conformer 2 20.55 A
 EC Number 2.7.11.1  
Click here to see the DynDom results or the famliy
 Trigger ligands ADP1509
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact No
 Spanning ligands No
 Residues in enzyme contacting ligands ALA230  ALA247  ASN352  ASP368  CYS231  GLU302  GLU308  GLU351  GLY227  GLY229  GLY232  ILE286  LEU226  LEU301  LEU303  LEU354  LYS249  MET304  SER228  VAL234 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT