Undecaprenyl pyrophosphate synthetase
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1x09(A) : LSEKLPAHGCRHVAIIMAGNGRWAKKQGKIRAFGHKAGAKSVRRAVSFAA 
         :                                                    
 1jp3(B) : ********GCRHVAII-dGNGRWAKKQGKIRAFGHKAGAKSVRRAVSFAA 
           __________________________________________________ 

           ______66__________________________________________ 
 1x09(A) : NNGIEALTLYAFSSENWNRPAQEVSALMELFVWALDSEVKSLHRHNVRLR 
         :                                                    
 1jp3(B) : NNGIEALTLYAFSsA------------LeLFVWALDSEVKSLHRHNVRLR 
           ______66__________________________________________ 

           ______________________________141_________________ 
 1x09(A) : IIGDTSRFNSRLQERIRKSEALTAGNTGLTLNIAANYGGRWDIVQGVRQL 
         :                                                    
 1jp3(B) : IIGDTSRFNSRLQERIRKSEALTAGNTGLTLNIAANYGGRWDIVQGVRQL 
           ______________________________141_________________ 

           __________________________________________________ 
 1x09(A) : AEKVQQGNLQPDQIDEEMLNQHVCMHELAPVDLVIRTGGEHRISNFLLWQ 
         :                                                    
 1jp3(B) : AEKVQQGNLQPDQIDEE-lNQHVC-hELAPVDLVIRTGGEHRISNFLLWQ 
           __________________________________________________ 

           _______________________________                    
 1x09(A) : IAYAELYFTDVLWPDFDEQDFEGALNAFANR                    
         :                                                    
 1jp3(B) : IAYAELYFTDVLWPDFDEQDFEGALNAFAN*                    
           _______________________________                    

Details

  Property   Value
 Conformer 1 1x09(A)
 Conformer 2 1jp3(B)
 Radius gyration for conformer 1 17.85 A
 Radius gyration for conformer 2 18.05 A
 EC Number 2.5.1.31  
Click here to see the DynDom results or the famliy
 Trigger ligands IPE902
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA26  ALA69  ARG194  ARG200  ARG77  ASN74  ILE24  MET25  PHE70  SER202  TYR68 
 Residues in extended bending regions contacting ligands ALA69  ASN74  PHE70  TYR68 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ASN74 
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT