Cytochrome P450-cam
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1k2o(A) : ANLAPLPPHVPEHLVFDFDMYNPSNLSAGVQEAWAVLQESNVPDLVWTRC 
         :                                                    
 2frz(B) : *NLAPLPPHVPEHLVFDFDMYNPSNLSAGVQEAWAVLQESNVPDLVWTRC 
           __________________________________________________ 

           ___________________________87__________99_________ 
 1k2o(A) : NGGHWIATRGQLIREAYEDYRHFSSECPFIPREAGEAYDFIPTSMDPPEQ 
         :                                                    
 2frz(B) : NGGHWIATRGQLIREAYEDYRHFSSECPWIPREAGEAFDFIPTSMDPPEQ 
           ___________________________87__________99_________ 

           111____118__________131_______________________157_ 
 1k2o(A) : RQFRALANQVVGMPVVDKLENRIQELACSLIESLRPQGQCNFTEDYAEPF 
         :                                                    
 2frz(B) : RQFRALANQVVGMPVVDKLENRIQELACSLIESLRPQGQCNFTEDYAEPF 
           111____118__________131_______________________157_ 

           __________________________________________________ 
 1k2o(A) : PIRIFMLLAGLPEEDIPHLKYLTDQMTRPDGSMTFAEAKEALYDYLIPII 
         :                                                    
 2frz(B) : PIRIFMLLAGLPEEDIPHLKYLTDQMTRPDGSMTFAEAKEALYDYLIPII 
           __________________________________________________ 

           ________________________________________251_______ 
 1k2o(A) : EQRRQKPGTDAISIVANGQVNGRPITSDEAKRMCGLLLVGGLDTVVNFLS 
         :                                                    
 2frz(B) : EQRRQKPGTDAISIVANGQVNGRPITSDEAKRMCGLLLLGGLDTVVNFLS 
           ________________________________________251_______ 

           __________________________________________________ 
 1k2o(A) : FSMEFLAKSPEHRQELIERPERIPAACEELLRRFSLVADGRILTSDYEFH 
         :                                                    
 2frz(B) : FSMEFLAKSPEHRQELIERPERIPAACEELLRRFSLVADGRILTSDYEFH 
           __________________________________________________ 

           __________________________________________________ 
 1k2o(A) : GVQLKKGDQILLPQMLSGLDERENAAPMHVDFSRQKVSHTTFGHGSHLCL 
         :                                                    
 2frz(B) : GVQLKKGDQILLPQMLSGLDERENAAPMHVDFSRQKVSHTTFGHGSHLCL 
           __________________________________________________ 

           __________________________________________________ 
 1k2o(A) : GQHLARREIIVTLKEWLTRIPDFSIAPGAQIQHKSGIVSGVQALPLVWDP 
         :                                                    
 2frz(B) : GQHLARREIIVTLKEWLTRIPDFSIAPGAQIQHKSGIVSGVQALPLVWDP 
           __________________________________________________ 

           ______                                             
 1k2o(A) : ATTKAV                                             
         :                                                    
 2frz(B) : ATTKAV                                             
           ______                                             

Details

  Property   Value
 Conformer 1 1k2o(A)
 Conformer 2 2frz(B)
 Radius gyration for conformer 1 21.59 A
 Radius gyration for conformer 2 21.24 A
 EC Number 1.14.15.1  
Click here to see the DynDom results or the famliy
 Trigger ligands HEM417
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact No
 Spanning ligands Yes
 Residues in enzyme contacting ligands
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ARG112 
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT