4-DIPHOSPHOCYTIDYL-2-C-METHYLERYTHRITOL SYNTH
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           _________14_______________________________47______ 
 1ini(A) : THLDVCAVVPAAGFGRRMQTECPKQYLSIGNQTILEHSVHALLAHPRVKR 
         :                                                    
 1vgt(A) : **LDVCAVVPAA----------pKQYLSIGNQTILEHSVHALLAHPRVKR 
           _________14_______________________________47______ 

           __________65__69_______________________________103 
 1ini(A) : VVIAISPGDSRFAQLPLANHPQITVVDGGDERADSVLAGLKAAGDAQWVL 
         :                                                    
 1vgt(A) : VVIAIS---sRFAQLPLANHPQITVVDGGDERADSVLAGLKAAGDAQWVL 
           __________65__69_______________________________103 

           _______________121________________________________ 
 1ini(A) : VHDAARPCLHQDDLARLLALSETSRTGGILAAPVRDTMKRAEPGKNAIAH 
         :                                                    
 1vgt(A) : VHDAARPCLHQDDLARLLALSETSRTGGILAAPVRDTMKRAEPGKNAIAH 
           _______________121________________________________ 

           __________166_____________________190_____________ 
 1ini(A) : TVDRNGLWHALTPQFFPRELLHDCLTRALNEGATITDEASALEYCGFHPQ 
         :                                                    
 1vgt(A) : TVDRNGLWHALTPQFFPRELLHDCLTRALNEGATITDEASALEYCGFHPQ 
           __________166_____________________190_____________ 

           _________________________                          
 1ini(A) : LVEGRADNIKVTRPEDLALAEFYLT                          
         :                                                    
 1vgt(A) : LVEGRADNIKVT--eDLALAEFYL*                          
           _________________________                          

Details

  Property   Value
 Conformer 1 1ini(A)
 Conformer 2 1vgt(A)
 Radius gyration for conformer 1 17.35 A
 Radius gyration for conformer 2 17.51 A
 EC Number 2.7.7.60  
Click here to see the DynDom results or the famliy
 Trigger ligands CDM1001
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA107  ALA108  ALA14  ALA15  ALA163  ARG109  ARG20  ARG85  ASP106  ASP190  ASP83  GLU84  GLY16  GLY82  LYS213  LYS27  PRO13  SER88  THR165  THR189  THR215 
 Residues in extended bending regions contacting ligands ALA107  ALA14  ALA15  ALA163  ASP106  ASP190  GLY16  LYS27  PRO13  THR165  THR189 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ALA107  ALA15  ALA163  ASP106  GLY16  LYS27  PRO13  THR189 
  Residues in extended bending regions with an H-bond between its main chain and ligands ALA107  ALA15  ALA163  GLY16  PRO13  THR189 
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT