D-LACTATE DEHYDROGENASE
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1j49(B) : MTKIFAYAIREDEKPFLKEWEDAHKDVEVEYTDKLLTPETVALAKGADGV 
         :                                                    
 1j4a(D) : *TKIFAYAIREDEKPFLKEWEDAHKDVEVEYTDKLLTPETVALAKGADGV 
           __________________________________________________ 

           _______________________________________________100 
 1j49(B) : VVYQQLDYIAETLQALADNGITKMSLRNVGVDNIDMAKAKELGFQITNVP 
         :                                                    
 1j4a(D) : VVYQQLDYIAETLQALADNGITKMSLRNVGVDNIDMAKAKELGFQITNVP 
           _______________________________________________100 

           __________________________________________________ 
 1j49(B) : VYSPNAIAEHAAIQAARILRQDKAMDEKVARHDLRWAPTIGREVRDQVVG 
         :                                                    
 1j4a(D) : VYSPNAIAEHAAIQAARILRQDKAMDEKVARHDLRWAPTIGREVRDQVVG 
           __________________________________________________ 

           __________________________________________________ 
 1j49(B) : VVGTGHIGQVFMQIMEGFGAKVITYDIFRNPELEKKGYYVDSLDDLYKQA 
         :                                                    
 1j4a(D) : VVGTGHIGQVFMQIMEGFGAKVITYDIFRNPELEKKGYYVDSLDDLYKQA 
           __________________________________________________ 

           __________________________________________________ 
 1j49(B) : DVISLHVPDVPANVHMINDESIAKMKQDVVIVNVSRGPLVDTDAVIRGLD 
         :                                                    
 1j4a(D) : DVISLHVPDVPANVHMINDESIAKMKQDVVIVNVSRGPLVDTDAVIRGLD 
           __________________________________________________ 

           _________________________________________________3 
 1j49(B) : SGKIFGYAMDVYEGEVGIFNEDWEGKEFPDARLADLIARPNVLVTPHTAF 
         :                                                    
 1j4a(D) : SGKIFGYAMDVYEGEVGIFNEDWEGKEFPDARLADLIARPNVLVTPKTAF 
           _________________________________________________3 

           02_______________________________                  
 1j49(B) : YTTHAVRNMVVKAFDNNLELVEGKEAETPVKV*                  
         :                                                    
 1j4a(D) : YTTHAVRNMVVKAFDNNLELVEGKEAETPVKVG                  
           02_______________________________                  

Details

  Property   Value
 Conformer 1 1j49(B)
 Conformer 2 1j4a(D)
 Radius gyration for conformer 1 21.44 A
 Radius gyration for conformer 2 22.9 A
 EC Number 1.1.1.28  
Click here to see the DynDom results or the famliy
 Trigger ligands NAD360
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA299  ARG236  ASN213  ASP176  ASP260  GLY153  GLY155  HIS156  HIS206  HIS297  ILE107  ILE157  ILE177  PHE178  PHE300  PRO208  SER235  THR154  TYR102  TYR175  VAL152  VAL207  VAL234  VAL261  VAL79 
 Residues in extended bending regions contacting ligands ALA299  ILE107  PHE300  TYR102 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands PHE300 
  Residues in extended bending regions with an H-bond between its main chain and ligands PHE300 
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT