enolase 1
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1ebh(B) : AVSKVYARSVYDSRGNPTVEVELTTEKGVFRSIVPSGASTGVHEALEMRD 
         :                                                    
 1one(A) : AVSKVYARSVYDSRGNPTVEVELTTEKGVFRSIVPSGASTGVHEALEMRD 
           __________________________________________________ 

           __________________________________________________ 
 1ebh(B) : GDKSKWMGKGVLHAVKNVNDVIAPAFVKANIDVKDQKAVDDFLISLDGTA 
         :                                                    
 1one(A) : GDKSKWMGKGVLHAVKNVNDVIAPAFVKANIDVKDQKAVDDFLISLDGTA 
           __________________________________________________ 

           _________________________________________________1 
 1ebh(B) : NKSKLGANAILGVSLAASRAAAAEKNVPLYKHLADLSKSKTSPYVLPVPF 
         :                                                    
 1one(A) : NKSKLGANAILGVSLAASRAAAAEKNVPLYKHLADLSKSKTSPYVLPVPF 
           _________________________________________________1 

           52______________169_______________________________ 
 1ebh(B) : LNVLNGGSHAGGALALQEFMIAPTGAKTFAEALRIGSEVYHNLKSLTKKR 
         :                                                    
 1one(A) : LNVLNGGSHAGGALALQEFMIAPTGAKTFAEALRIGSEVYHNLKSLTKKR 
           52______________169_______________________________ 

           __________213__________226______________243_______ 
 1ebh(B) : YGASAGNVGDEGGVAPNIQTAEEALDLIVDAIKAAGHDGKVKIGLDCASS 
         :                                                    
 1one(A) : YGASAGNVGDEGGVAPNIQTAEEALDLIVDAIKAAGHDGKVKIGLDCASS 
           __________213__________226______________243_______ 

           __________________________________________________ 
 1ebh(B) : EFFKDGKYDLDFKNPNSDKSKWLTGPQLADLYHSLMKRYPIVSIEDPFAE 
         :                                                    
 1one(A) : EFFKDGKYDLDFKNPNSDKSKWLTGPQLADLYHSLMKRYPIVSIEDPFAE 
           __________________________________________________ 

           _____________________________________340__________ 
 1ebh(B) : DDWEAWSHFFKTAGIQIVADDLTVTNPKRIATAIEKKAADALLLKVNQIG 
         :                                                    
 1one(A) : DDWEAWSHFFKTAGIQIVADDLTVTNPKRIATAIEKKAADALLLKVNQIG 
           _____________________________________340__________ 

           __________________________________________________ 
 1ebh(B) : TLSESIKAAQDSFAAGWGVMVSHRSGETEDTFIADLVVGLRTGQIKTGAP 
         :                                                    
 1one(A) : TLSESIKAAQDSFAAGWGVMVSHRSGETEDTFIADLVVGLRTGQIKTGAP 
           __________________________________________________ 

           ____________________________________               
 1ebh(B) : ARSERLAKLNQLLRIEEELGDNAVFAGENFHHGDKL               
         :                                                    
 1one(A) : ARSERLAKLNQLLRIEEELGDNAVFAGENFHHGDKL               
           ____________________________________               

Details

  Property   Value
 Conformer 1 1ebh(B)
 Conformer 2 1one(A)
 Radius gyration for conformer 1 21.5 A
 Radius gyration for conformer 2 21.05 A
 EC Number 4.2.1.11  
Click here to see the DynDom results or the famliy
 Trigger ligands PAG441
PEP440
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA38  ARG374  ASP246  ASP320  GLN167  GLU168  GLU211  GLU295  GLY37  HIS159  HIS373  LEU343  LYS345  LYS396  SER375  SER39  THR40 
 Residues in extended bending regions contacting ligands ASP246  GLN167  GLU168  GLU211  LEU343 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ASP246  GLN167  GLU168  GLU211 
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT