HYPOXANTHINE GUANINE PHOSPHORIBOSYL-TRANSFERA
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           _____9____________________________________47______ 
 1z7g(C) : SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVM 
         :                                                    
 1hmp(A) : SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVM 
           _____9____________________________________47______ 

           __57__________________77______________93___98_____ 
 1z7g(C) : KEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLK- 
         :                                                    
 1hmp(A) : KEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKS 
           __57__________________77______________93___98_____ 

           __________________________________________________ 
 1z7g(C) : ---------iKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYN 
         :                                                    
 1hmp(A) : YCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYN 
           __________________________________________________ 

           ______162________________181______________________ 
 1z7g(C) : PKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNH 
         :                                                    
 1hmp(A) : PKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNH 
           ______162________________181______________________ 

           ______________                                     
 1z7g(C) : VCVISETGKAKYKA                                     
         :                                                    
 1hmp(A) : VCVISETGKAKYKA                                     
           ______________                                     

Details

  Property   Value
 Conformer 1 1z7g(C)
 Conformer 2 1hmp(A)
 Radius gyration for conformer 1 17.78 A
 Radius gyration for conformer 2 17.85 A
 EC Number 2.4.2.8  
Click here to see the DynDom results or the famliy
 Trigger ligands 5GP300
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact No
 Spanning ligands Yes
 Residues in enzyme contacting ligands ASP134  ASP137  ASP193  GLU133  GLY139  ILE135  ILE136  LEU192  LYS140  LYS165  LYS185  LYS68  PHE186  THR138  THR141  VAL187 
 Residues in extended bending regions contacting ligands LYS165  LYS185 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands LYS165 
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT