THREONINE SYNTHASE
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1v7c(C) : MRPPLIERYRNLLPVSEKTPVISLLEGSTPLIPLKGPEEARKKGIRLYAK 
         :                                                    
 1uin(A) : *RPPLIERYRNLLPVSEKTPVISLLEGSTPLIPLKGPEEARKKGIRLYAK 
           __________________________________________________ 

           __________________________78_______87_____________ 
 1v7c(C) : YEGLNPTGSFKDRGMTLAVSKAVEGGAQAVACASTGNTAASAAAYAARAG 
         :                                                    
 1uin(A) : YEGLNPTGSFKDRGMTLAVSKAVEGGAQAVACASTGNTAASAAAYAARAG 
           __________________________78_______87_____________ 

           103_____________119__124________________________15 
 1v7c(C) : ILAIVVLPAGYVALGKVAQSLVHGARIVQVEGNFDDALRLTQKLTEAFPV 
         :                                                    
 1uin(A) : ILAIVVLPAGYVALGKVAQSLVHGARIVQVEGNFDDALRLTQKLTEAFPV 
           103_____________119__124________________________15 

           1_________________________________________________ 
 1v7c(C) : ALVNSVNPHRLEGQKTLAFEVVDELGDAPHYHALPVGNAGNITAHWMGYK 
         :                                                    
 1uin(A) : ALVNSVNPHRLEGQKTLAFEVVDELGDAPHYHALPVGNAGNITAHWMGYK 
           1_________________________________________________ 

           __________________________________________________ 
 1v7c(C) : AYHALGKAKRLPRMLGFQAAGAAPLVLGRPVERPETLATAIRIGNPASWQ 
         :                                                    
 1uin(A) : AYHALGKAKRLPRMLGFQAAGAAPLVLGRPVERPETLATAIRIGNPASWQ 
           __________________________________________________ 

           __________________________________________________ 
 1v7c(C) : GAVRAKEESGGVIEAVTDEEILFAYRYLAREEGIFCEPASAAAMAGVFKL 
         :                                                    
 1uin(A) : GAVRAKEESGGVIEAVTDEEILFAYRYLAREEGIFCEPASAAAMAGVFKL 
           __________________________________________________ 

           __________________________________________________ 
 1v7c(C) : LREGRLEPESTVVLTLTGHGLKDPATAERVAELPPPVPARLEAVAAAAGL 
         :                                                    
 1uin(A) : LREGRLEPESTVVLTLTGHGLKDPATAERVAELPPPVPARLEAVAAAAGL 
           __________________________________________________ 

           _                                                  
 1v7c(C) : L                                                  
         :                                                    
 1uin(A) : L                                                  
           _                                                  

Details

  Property   Value
 Conformer 1 1v7c(C)
 Conformer 2 1uin(A)
 Radius gyration for conformer 1 20.37 A
 Radius gyration for conformer 2 20.86 A
 EC Number 4.2.3.1  
Click here to see the DynDom results or the famliy
 Trigger ligands PLP513
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact No
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA189  ALA240  ALA289  ASN188  ASN191  ASN87  GLU287  GLY187  GLY190  GLY318  ILE241  LYS61  PHE60  SER59  THR317  VAL186 
 Residues in extended bending regions contacting ligands ASN87 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ASN87 
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT