D-ALANINE
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1ehi(A) : *KKRVALIFGGNSSEHDVSKRSAQNFYNAIEATGKYEIIVFAIAQNGFFL 
         :                                                    
 1ehi(B) : TKKRVALIFGGNSSEHDVSKRSAQNFYNAIEATGKYEIIVFAIAQNGFFL 
           __________________________________________________ 

           __________________________________________________ 
 1ehi(A) : DTESSKKILALEDEQPIVDAFMKTVDASDPLARIHALKSAGDFDIFFPVV 
         :                                                    
 1ehi(B) : DTESSKKILALEDEQPIVDAFMKTVDASDPLARIHALKSAGDFDIFFPVV 
           __________________________________________________ 

           ________________________________136_________148___ 
 1ehi(A) : HGNLGEDGTLQGLFKLLDKPYVGAPLRGHAVSFDKALTKELLTVNGIRNT 
         :                                                    
 1ehi(B) : HGNLGEDGTLQGLFKLLDKPYVGAPLRGHAVSFDKALTKELLTVNGIRNT 
           ________________________________536_________548___ 

           __________________________________________________ 
 1ehi(A) : KYIVVDPESANNWSWDKIVAELGNIVFVKAANQGSSVGISRVTNAEEYTE 
         :                                                    
 1ehi(B) : KYIVVDPESANNWSWDKIVAELGNIVFVKAANQGSSVGISRVTNAEEYTE 
           __________________________________________________ 

           _______________219_________________239____________ 
 1ehi(A) : ALSDSFQYDYKVLIEEAVNGARELEVGVIGNDQPLVSEIGAHTVPNQGSG 
         :                                                    
 1ehi(B) : ALSDSFQYDYKVLIEEAVNGARELEVGVIGNDQPLVSEIGAHTv------ 
           _______________619_________________639____________ 

           ______________________276_____284_________________ 
 1ehi(A) : DGWYDYNNKFVDNSAVHFQIPAQLSPEVTKEVKQMALDAYKVLNLRGEAR 
         :                                                    
 1ehi(B) : ----------------HFQIPAQLSPEVTKEVKQMALDAYKVLNLRGEAR 
           ______________________676_____684_________________ 

           ________312_316___________________________________ 
 1ehi(A) : MDFLLDENNVPYLGEPNTLPGFTNMSLFKRLWDYSDINNAKLVDMLIDYG 
         :                                                    
 1ehi(B) : MDFLLDENNVPYLGEPNTLPGFTNMSLFKRLWDYSDINNAKLVDMLIDYG 
           ________712_716___________________________________ 

           ___________________                                
 1ehi(A) : FEDFAQNKKLS********                                
         :                                                    
 1ehi(B) : FEDFAQNKKLSYSFVSLGE                                
           ___________________                                

Details

  Property   Value
 Conformer 1 1ehi(A)
 Conformer 2 1ehi(B)
 Radius gyration for conformer 1 20.92 A
 Radius gyration for conformer 2 21.21 A
 EC Number 6.3.2.4  
Click here to see the DynDom results or the famliy
 Trigger ligands ADP781
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA218  GLN184  GLN248  GLU216  GLU217  GLU224  GLU316  GLY185  ILE190  LEU305  LYS136  LYS180  LYS260  PHE178  SER186  SER187  THR151  TRP254  TYR255  VAL219 
 Residues in extended bending regions contacting ligands ALA218  GLN248  GLU216  GLU217  GLU224  GLU316  LYS136  THR151  VAL219 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands GLU216  GLU217  GLU224  GLU316  VAL219 
  Residues in extended bending regions with an H-bond between its main chain and ligands GLU217  VAL219 
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT