Ferrochelatase
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           ________74___79___________________________________ 
 2hre(D) : RKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKR 
         :                                                    
 2hrc(B) : RKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKR 
           _______574__579___________________________________ 

           _____122_______________________________________164 
 2hre(D) : RTPKIQEQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFR 
         :                                                    
 2hrc(B) : LTPKIQEQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFR 
           _____622_______________________________________664 

           __________________________________________________ 
 2hre(D) : YVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVG 
         :                                                    
 2hrc(B) : YVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVG 
           __________________________________________________ 

           __________________________________________________ 
 2hre(D) : RKPTMKWSTIDRWPTHHLLIQCFADHILKELDHFPLEKRSEVVILFSAHS 
         :                                                    
 2hrc(B) : RKPTMKWSTIDRWPTHHLLIQCFADHILKELDHFPLEKRSEVVILFSAHS 
           __________________________________________________ 

           __________________________________________________ 
 2hre(D) : LPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLVWQSKVGPMPWLGPQ 
         :                                                    
 2hrc(B) : LPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLVWQSKVGPMPWLGPQ 
           __________________________________________________ 

           __________________________________________________ 
 2hre(D) : TDESIKGLCERGRKNILLVPIAFTSDHIKTLYELDIEYSQVLAKECGVEN 
         :                                                    
 2hrc(B) : TDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKECGVEN 
           __________________________________________________ 

           __________________________________________________ 
 2hre(D) : IRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRET 
         :                                                    
 2hrc(B) : IRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRET 
           __________________________________________________ 

           _________                                          
 2hre(D) : KSFFTSQQL                                          
         :                                                    
 2hrc(B) : KSFFTSQQL                                          
           _________                                          

Details

  Property   Value
 Conformer 1 2hre(D)
 Conformer 2 2hrc(B)
 Radius gyration for conformer 1 20.53 A
 Radius gyration for conformer 2 20.63 A
 EC Number 4.99.1.1  
Click here to see the DynDom results or the famliy
 Trigger ligands PP9604
PP9606
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA336  ARG115  GLY306  GLY77  GLY78  HIS263  HIS341  ILE111  ILE119  ILE132  ILE342  LEU265  LEU89  LEU92  LEU98  LYS343  MET308  MET76  MET99  PHE110  PHE337  PHE88  PHE93  PRO102  PRO266  PRO307  SER130  SER197  THR198  TRP310  TYR123  TYR191  TYR276  VAL305 
 Residues in extended bending regions contacting ligands GLY77  GLY78  ILE119  ILE132  MET76  SER130  TYR123 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands SER130  TYR123 
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT