NITRIC OXIDE SYNTHASE
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1noc(A) : ***************************************PKSLTRGPRDK 
         :                                                    
 1vaf(A) : QYVRIKNWGSGEILHDTLHHKATSDFTCKSKSCLGSIMNPKSLTRGPRDK 
           __________________________________________________ 

           __________________________________________________ 
 1noc(A) : PTPLEELLPHAIEFINQYYGSFKEAKIEEHLARLEAVTKEIETTGTYQLT 
         :                                                    
 1vaf(A) : PTPLEELLPHAIEFINQYYGSFKEAKIEEHLARLEAVTKEIETTGTYQLT 
           __________________________________________________ 

           __________________________________________________ 
 1noc(A) : LDELIFATKMAWRNAPRCIGRIQWSNLQVFDARNCSTAQEMFQHICRHIL 
         :                                                    
 1vaf(A) : LDELIFATKMAWRNAPRCIGRIQWSNLQVFDARNCSTAQEMFQHICRHIL 
           __________________________________________________ 

           __________________________________________________ 
 1noc(A) : YATNNGNIRSAITVFPQRSDGKHDFRLWNSQLIRYAGYQMPDGTIRGDAA 
         :                                                    
 1vaf(A) : YATNNGNIRSAITVFPQRSDGKHDFRLWNSQLIRYAGYQMPDGTIRGDAA 
           __________________________________________________ 

           __________________________________________________ 
 1noc(A) : TLEFTQLCIDLGWKPRYGRFDVLPLVLQADGQDPEVFEIPPDLVLEVTME 
         :                                                    
 1vaf(A) : TLEFTQLCIDLGWKPRYGRFDVLPLVLQADGQDPEVFEIPPDLVLEVTME 
           __________________________________________________ 

           __________________________________________________ 
 1noc(A) : HPKYEWFQELGLKWYALPAVANMLLEVGGLEFPACPFNGWYMGTEIGVRD 
         :                                                    
 1vaf(A) : HPKYEWFQELGLKWYALPAVANMLLEVGGLEFPACPFNGWYMGTEIGVRD 
           __________________________________________________ 

           _________________________________________________4 
 1noc(A) : FCDTQRYNILEEVGRRMGLETHTLASLWKDRAVTEINVAVLHSFQKQNVT 
         :                                                    
 1vaf(A) : FCDTQRYNILEEVGRRMGLETHTLASLWKDRAVTEINVAVLHSFQKQNVT 
           _________________________________________________4 

           28____________________________459_________________ 
 1noc(A) : IMDHHTASESFMKHMQNEYRAR---------lVPPVSGSITPVFHQEMLN 
         :                                                    
 1vaf(A) : IMDHHTASESFMKHMQNEYRARGGCPADWIWLVPPVSGSITPVFHQEMLN 
           28____________________________459_________________ 

           ____________________                               
 1noc(A) : YVLSPFYYYQIEPWKTHIWQ                               
         :                                                    
 1vaf(A) : YVLSPFYYYQIEPWKTHIW*                               
           ____________________                               

Details

  Property   Value
 Conformer 1 1noc(A)
 Conformer 2 1vaf(A)
 Radius gyration for conformer 1 23.23 A
 Radius gyration for conformer 2 22.38 A
 EC Number 1.14.13.39  
Click here to see the DynDom results or the famliy
 Trigger ligands H4B901
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands No
 Residues in enzyme contacting ligands ARG375  ILE456  MET114  SER112  TRP457 
 Residues in extended bending regions contacting ligands ILE456  TRP457 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ILE456  TRP457 
  Residues in extended bending regions with an H-bond between its main chain and ligands ILE456  TRP457 
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT