phosphoenolpyruvate carboxykinase [ATP]
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1ytm(B) : SLSESLAKYGITGATNIVHNPSHEELFAAETQASLEGFEKGTVTEMGAVN 
         :                                                    
 1yvy(A) : SLSESLAKYGITGATNIVHNPSHEELFAAETQASLEGFEKGTVTEMGAVN 
           __________________________________________________ 

           __________________________________________________ 
 1ytm(B) : VMTGVYTGRSPKDKFIVKNEASKEIWWTSDEFKNDNKPVTEEAWAQLKAL 
         :                                                    
 1yvy(A) : VMTGVYTGRSPKDKFIVKNEASKEIWWTSDEFKNDNKPVTEEAWAQLKAL 
           __________________________________________________ 

           __________________________________________________ 
 1ytm(B) : AGKELSNKPLYVVDLFCGANENTRLKIRFVMEVAWQAHFVTNMFIRPTEE 
         :                                                    
 1yvy(A) : AGKELSNKPLYVVDLFCGANENTRLKIRFVMEVAWQAHFVTNMFIRPTEE 
           __________________________________________________ 

           __________________________________________________ 
 1ytm(B) : ELKGFEPDFVVLNASKAKVENFKELGLNSETAVVFNLAEKMQIILNTWYG 
         :                                                    
 1yvy(A) : ELKGFEPDFVVLNASKAKVENFKELGLNSETAVVFNLAEKMQIILNTWYG 
           __________________________________________________ 

           __________________________________1239____1247____ 
 1ytm(B) : GEMKKGMFSMMNFYLPLQGIAAMHCSANTDLEGKNTAIFFGLSGTGKTTL 
         :                                                    
 1yvy(A) : GEMKKGMFSMMNFYLPLQGIAAMHCSANTDLEGKNTAIFFGLSGTGKTTL 
           ___________________________________239_____247____ 

           __________________________________________________ 
 1ytm(B) : STDPKRLLIGDDEHGWDDDGVFNFEGGCYAKVINLSKENEPDIWGAIKRN 
         :                                                    
 1yvy(A) : STDPKRLLIGDDEHGWDDDGVFNFEGGCYAKVINLSKENEPDIWGAIKRN 
           __________________________________________________ 

           ____________________________________________1349__ 
 1ytm(B) : ALLENVTVDANGKVDFADKSVTENTRVSYPIFHIKNIVKPVSKAPAAKRV 
         :                                                    
 1yvy(A) : ALLENVTVDANGKVDFADKSVTENTRVSYPIFHIKNIVKPVSKAPAAKRV 
           _____________________________________________349__ 

           _____________________________________________1400_ 
 1ytm(B) : IFLSADAFGVLPPVSILSKEQTKYYFLSGFTAKLAGTERGITEPTPTFSS 
         :                                                    
 1yvy(A) : IFLSADAFGVLPPVSILSKEQTKYYFLSGFTAK----------pTPTFSS 
           ______________________________________________400_ 

           ________________________1429______________________ 
 1ytm(B) : CFGAAFLTLPPTKYAEVLVKRMEASGAKAYLVNTGWNGTGKRISIKDTRG 
         :                                                    
 1yvy(A) : CFGAAFLTLPPTKYAEVLVKRMEASGAKAYLVNTGWNGTGKRISIKDTRG 
           _________________________429______________________ 

           __________________________________________________ 
 1ytm(B) : IIDAILDGSIDTANTATIPYFNFTVPTELKGVDTKILDPRNTYADASEWE 
         :                                                    
 1yvy(A) : IIDAILDGSIDTANTATIPYFNFTVPTELKGVDTKILDPRNTYADASEWE 
           __________________________________________________ 

           _________________                                  
 1ytm(B) : VKAKDLAERFQKNFKKF                                  
         :                                                    
 1yvy(A) : VKAKDLAERFQKNFKKF                                  
           _________________                                  

Details

  Property   Value
 Conformer 1 1ytm(B)
 Conformer 2 1yvy(A)
 Radius gyration for conformer 1 22.65 A
 Radius gyration for conformer 2 22.92 A
 EC Number 4.1.1.49  
Click here to see the DynDom results or the famliy
 Trigger ligands OXD1543
ATP1541
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ARG1060  ARG1327  ARG1443  ASP1263  GLY1245  GLY1247  HIS1225  ILE1444  ILE1446  LEU1243  LYS1206  LYS1248  LYS1282  PHE1407  SER1244  SER1445  THR1246  THR1249  THR1250  THR1435  THR1449  TYR1200  TYR1280 
 Residues in extended bending regions contacting ligands GLY1245  GLY1247  LEU1243  LYS1248  SER1244  THR1246  THR1249  THR1250 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands GLY1245  GLY1247  LYS1248  SER1244  THR1246  THR1249  THR1250 
  Residues in extended bending regions with an H-bond between its main chain and ligands GLY1245  GLY1247  LYS1248  THR1246  THR1249  THR1250 
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT