ADP-ribosyl cyclase 1
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 2o3s(B) : FWRQTWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFI 
         :                                                    
 2i67(B) : RWRQTWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFI 
           __________________________________________________ 

           ________________________121__________________142__ 
 2o3s(B) : SKHPCDITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFT 
         :                                                    
 2i67(B) : SKHPCDITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFT 
           ________________________121__________________142__ 

           __________________________________________________ 
 2o3s(B) : LEDTLLGYLADDLTWCGEFDTSKINYQSCPDWRKDCSNNPVSVFWKTVSR 
         :                                                    
 2i67(B) : LEDTLLGYLADDLTWCGEFDTSKINYQSCPDWRKDCSNNPVSVFWKTVSR 
           __________________________________________________ 

           ______203_______________221____________236________ 
 2o3s(B) : RFAEAACDVVHVMLDGSRSKIFDKDSTFGSVGVHNLQPEKVQTLEAWVIH 
         :                                                    
 2i67(B) : RFAEAACDVVHVMLDGSRSKIFDKDSTFGSVEVHNLQPEKVQTLEAWVIH 
           ______203_______________221____________236________ 

           __________________________________________________ 
 2o3s(B) : GGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDS 
         :                                                    
 2i67(B) : GGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPE** 
           __________________________________________________ 

           __                                                 
 2o3s(B) : SC                                                 
         :                                                    
 2i67(B) : **                                                 
           __                                                 

Details

  Property   Value
 Conformer 1 2o3s(B)
 Conformer 2 2i67(B)
 Radius gyration for conformer 1 19.82 A
 Radius gyration for conformer 2 19.18 A
 EC Number 3.2.2.5  
Click here to see the DynDom results or the famliy
 Trigger ligands APR302
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ARG212  ASP155  ASP156  GLU146  LYS129  THR221  TRP125  TRP189  VAL185 
 Residues in extended bending regions contacting ligands GLU146  THR221  TRP125 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands GLU146  THR221 
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT