ASPARTYL-TRNA SYNTHETASE
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1g51(B) : MRRTHYAGSLRETHVGEEVVLEGWVNRRRDLGGLIFLDLRDREGLVQLVA 
         :                                                    
 1efw(A) : MRRTHYAGSLRETHVGEEVVLEGWVNRRRDLGGLIFLDLRDREGLVQLVA 
           __________________________________________________ 

           __________________________________________________ 
 1g51(B) : HPASPAYATAERVRPEWVVRAKGLVRLRPEPNPRLATGRVEVELSALEVL 
         :                                                    
 1efw(A) : HPASPAYATAERVRPEWVVRAKGLVRLRPEPNPRLATGRVEVELSALEVL 
           __________________________________________________ 

           __________________________________________________ 
 1g51(B) : AEAKTPPFPVDAGWRGEEEKEASEELRLKYRYLDLRRRRMQENLRLRHRV 
         :                                                    
 1efw(A) : AEAKTPPFPVDAGWRGEEEKEASEELRLKYRYLDLRRRRMQENLRLRHRV 
           __________________________________________________ 

           __________________________________________________ 
 1g51(B) : IKAIWDFLDREGFVQVETPFLTKSTPEGARDFLVPYRHEPGLFYALPQSP 
         :                                                    
 1efw(A) : IKAIWDFLDREGFVQVETPFLTKSTPEGARDFLVPYRHEPGLFYALPQSP 
           __________________________________________________ 

           __________________________________________________ 
 1g51(B) : QLFKQMLMVAGLDRYFQIARCFRDEDLRADRQPDFTQLDLEMSFVEVEDV 
         :                                                    
 1efw(A) : QLFKQMLMVAGLDRYFQIARCFRDEDLRADRQPDFTQLDLEMSFVEVEDV 
           __________________________________________________ 

           _____________________________________________1299_ 
 1g51(B) : LELNERLMAHVFREALGVELPLPFPRLSYEEAMERYGSDKPDLRFGLELK 
         :                                                    
 1efw(A) : LELNERLMAHVFREALGVELPLPFPRLSYEEAMERYGSDKPDLRFGLELK 
           ______________________________________________299_ 

           __________________________________________________ 
 1g51(B) : EVGPLFRQSGFRVFQEAESVKALALPKALSRKEVAELEEVAKRHKAQGLA 
         :                                                    
 1efw(A) : EVGPLFRQSGFRVFQEAESVKALALPKALSRKEVAELEEVAKRHKAQGLA 
           __________________________________________________ 

           ________________________________________________14 
 1g51(B) : WARVEEGGFSGGVAKFLEPVREALLQATEARPGDTLLFVAGPRKVAATAL 
         :                                                    
 1efw(A) : WARVEEGGFSGGVAKFLEPVREALLQATEARPGDTLLFVAGPRKVAATAL 
           _________________________________________________4 

           02_1407___________________________________________ 
 1g51(B) : GAVRLRAADLLGLKREGFRFLWVVDFPLLEWDEEEEAWTYMHHPFTSPHP 
         :                                                    
 1efw(A) : GAVRLRAADLLGLKREGFRFLWVVDFPLLEWDEEEEAWTYMHHPFTSPHP 
           02__407___________________________________________ 

           __________________________________________________ 
 1g51(B) : EDLPLLEKDPGRVRALAYDLVLNGVEVGGGSIRIHDPRLQARVFRLLGIG 
         :                                                    
 1efw(A) : EDLPLLEKDPGRVRALAYDLVLNGVEVGGGSIRIHDPRLQARVFRLLGIG 
           __________________________________________________ 

           __________________________________________________ 
 1g51(B) : EEEQREKFGFFLEALEYGAPPHGGIAWGLDRLLALMTGSPSIREVIAFPK 
         :                                                    
 1efw(A) : EEEQREKFGFFLEALEYGAPPHGGIAWGLDRLLALMTGSPSIREVIAFPK 
           __________________________________________________ 

           ______________________________                     
 1g51(B) : NKEGKDPLTGAPSPVPEEQLRELGLMVVRP                     
         :                                                    
 1efw(A) : NKEGKDPLTGAPSPVPEEQLRELGLMVVRP                     
           ______________________________                     

Details

  Property   Value
 Conformer 1 1g51(B)
 Conformer 2 1efw(A)
 Radius gyration for conformer 1 29.58 A
 Radius gyration for conformer 2 29.77 A
 EC Number 6.1.1.12  
Click here to see the DynDom results or the famliy
 Trigger ligands AMP800
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands No
 Residues in enzyme contacting ligands ALA1350  ALA1390  GLN1347  GLU1338  GLY1348  LEU1349  PHE1311  PHE1388  VAL1313  VAL1389 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT