Bifunctional P-450
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1jpz(B) : TIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTR 
         :                                                    
 1bvy(A) : *******************LNTDKPVQALMKIADELGEIFKFEAPGRVTR 
           __________________________________________________ 

           __________________________________________________ 
 1jpz(B) : YLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAH 
         :                                                    
 1bvy(A) : YLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAH 
           __________________________________________________ 

           __________________________________________________ 
 1jpz(B) : NILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTL 
         :                                                    
 1bvy(A) : NILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTL 
           __________________________________________________ 

           ______________________175_____183_________________ 
 1jpz(B) : DTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDE 
         :                                                    
 1bvy(A) : DTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDE 
           ______________________175_____183_________________ 

           _______210________________________________________ 
 1jpz(B) : NKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLD 
         :                                                    
 1bvy(A) : NKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLD 
           _______210________________________________________ 

           __________________________________________________ 
 1jpz(B) : DENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVD 
         :                                                    
 1bvy(A) : DENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVD 
           __________________________________________________ 

           __________________________________________________ 
 1jpz(B) : PVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKG 
         :                                                    
 1bvy(A) : PVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKG 
           __________________________________________________ 

           __________________________________________________ 
 1jpz(B) : DELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRAC 
         :                                                    
 1bvy(A) : DELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRAC 
           __________________________________________________ 

           __________________________________________________ 
 1jpz(B) : IGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKS 
         :                                                    
 1bvy(A) : IGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKS 
           __________________________________________________ 

           ________                                           
 1jpz(B) : KKIPLGGI                                           
         :                                                    
 1bvy(A) : KKIPLGGI                                           
           ________                                           

Details

  Property   Value
 Conformer 1 1jpz(B)
 Conformer 2 1bvy(A)
 Radius gyration for conformer 1 21.69 A
 Radius gyration for conformer 2 21.94 A
 EC Number 1.14.14.1  
Click here to see the DynDom results or the famliy
 Trigger ligands HEM1000
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact No
 Spanning ligands No
 Residues in enzyme contacting ligands ALA264  ALA328  ALA399  ALA406  ARG398  CYS400  GLY265  GLY394  GLY402  ILE401  LEU272  LEU86  LYS69  PHE107  PHE261  PHE331  PHE393  PHE87  PRO392  THR260  THR268  THR269  THR327  TRP96 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT