autocrine motility factor
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1jlh(C) : AALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHI 
         :                                                    
 1g98(A) : AALTRNPQFQKLQQWHREHGSELNLRHLFDTDKERFNHFSLTLNTNHGHI 
           __________________________________________________ 

           __________________________________________________ 
 1jlh(C) : LVDYSKNLVTEDVMRMLVDLAKSRGVEAARERMFNGEKINYTEGRAVLHV 
         :                                                    
 1g98(A) : LLDYSKNLVTEEVMHMLLDLAKSRGVEAARESMFNGEKINSTEDRAVLHV 
           __________________________________________________ 

           __________________________________________________ 
 1jlh(C) : ALRNRSNTPILVDGKDVMPEVNKVLDKMKSFCQRVRSGDWKGYTGKTITD 
         :                                                    
 1g98(A) : ALRNRSNTPIVVDGKDVMPEVNKVLDKMKAFCQRVRSGDWKGYTGKTITD 
           __________________________________________________ 

           __________________________________________________ 
 1jlh(C) : VINIGIGGSDLGPLMVTEALKPYSSGGPRVWYVSNIDGTHIAKTLAQLNP 
         :                                                    
 1g98(A) : VINIGIGGSDLGPLMVTEALKPYSSGGPRVWFVSNIDGTHIAKTLACLNP 
           __________________________________________________ 

           __________________________________________________ 
 1jlh(C) : ESSLFIIASKTFTTQETITNAETAKEWFLQAAKDPSAVAKHFVALSTNTT 
         :                                                    
 1g98(A) : ESSLFIIASKTFTTQETITNAKTAKDWFLLSAKDPSTVAKHFVALSTNTA 
           __________________________________________________ 

           __________________________________________________ 
 1jlh(C) : KVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDNFEQLLSGAH 
         :                                                    
 1g98(A) : KVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDNFEQLLSGAH 
           __________________________________________________ 

           __________________________________________________ 
 1jlh(C) : WMDQHFRTTPLEKNAPVLLALLGIWYINCFGCETHAMLPYDQYLHRFAAY 
         :                                                    
 1g98(A) : WMDQHFRTTPLEKNAPVLLAMLGIWYINCFGCETQAVLPYDQYLHRFAAY 
           __________________________________________________ 

           __________________________________________________ 
 1jlh(C) : FQQGDMESNGKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLIHQGTEM 
         :                                                    
 1g98(A) : FQQGDMESNGKYITKSGARVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKM 
           __________________________________________________ 

           ______________________________________441_________ 
 1jlh(C) : IPCDFLIPVQTQHPIRKGLHHKILLANFLAQTEALMRGKSTEEARKELQA 
         :                                                    
 1g98(A) : IPCDFLIPVQTQHPIRKGLHHKILLANFLAQTEALMKGKSTEEARKELQA 
           ______________________________________441_________ 

           __________463_____________________________________ 
 1jlh(C) : AGKSPEDLERLLPHKVFEGNRPTNSIVFTKLTPFMLGALVAMYEHKIFVQ 
         :                                                    
 1g98(A) : AGKSPEDLMKLLPHKVFEGNRPTNSIVFTKLTPFILGALIAMYEHKIFVQ 
           __________463_____________________________________ 

           __________________________________________________ 
 1jlh(C) : GIIWDINSFDQWGVELGKQLAKKIEPELDGSAQVTSHDASTNGLINFIKQ 
         :                                                    
 1g98(A) : GVVWDINSFDQWGVELGKQLAKKIEPELDGSSPVTSHDSSTNGLINFIKQ 
           __________________________________________________ 

           ______                                             
 1jlh(C) : QREARV                                             
         :                                                    
 1g98(A) : QREAK*                                             
           ______                                             

Details

  Property   Value
 Conformer 1 1jlh(C)
 Conformer 2 1g98(A)
 Radius gyration for conformer 1 26.05 A
 Radius gyration for conformer 2 25.97 A
 EC Number 5.3.1.9  
Click here to see the DynDom results or the famliy
 Trigger ligands PA51
PA52
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands No
 Residues in enzyme contacting ligands GLN353  GLN511  GLU357  GLY157  GLY158  HIS388  ILE156  LYS210  LYS518  SER159  SER209  THR211  THR214  VAL514 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT