RNA uridylyl transferase
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           _________________________29__________________49___ 
 2ikf(B) : PSPAVVGRSLVNSFKQFVSKDLHTRHVDATYRLVLDCVAAVD--mRLYTF 
         :                                                    
 2ikf(A) : PSPAVVGRSLVNSFKQFVS-----rHVDATYRLVLDCVAAVDPLMRLYTF 
           _________________________29__________________49___ 

           ____58_______________________________91__95_______ 
 2ikf(B) : GSTVVYGVHEKGSDVDFVVLNKT-------------vAKGLQADILAKLA 
         :                                                    
 2ikf(A) : GSTVVYGVHEKGSDVDFVVLNKTDVEDGKGGDAATQVAKGLQADILAKLA 
           ____58_______________________________91__95_______ 

           __________________________________139_____________ 
 2ikf(B) : RVIRQKHLSWNVEEV-----pVVRVKGGGAVDFDITAYRRNGVRNSALLR 
         :                                                    
 2ikf(A) : RVIRQKHLSWNVEEVRRTRVPVVRVKGGGAVDFDITAYRRNGVRNSALLR 
           __________________________________139_____________ 

           __________________________________________________ 
 2ikf(B) : AYFEQNPPCRWLSMSIKRWSKQTGLNASVIGGSITSYGFNLMVVYYLLQR 
         :                                                    
 2ikf(A) : AYFEQNPPCRWLSMSIKRWSKQTGLNASVIGGSITSYGFNLMVVYYLLQR 
           __________________________________________________ 

           __________________________________________________ 
 2ikf(B) : NHLQFVPPSTIDVSRVEPLPPHLPLEEPADEGLELGTQVLDFLHFFLHEF 
         :                                                    
 2ikf(A) : NHLQFVPPSTIDVSRVEPLPPHLPLEEPADEGLELGTQVLDFLHFFLHEF 
           __________________________________________________ 

           __________________________________________________ 
 2ikf(B) : DSDKQVISLNRPGITTKEELDWTKSAEDFARMNGEKVHYQWCIEDPYELN 
         :                                                    
 2ikf(A) : DSDKQVISLNRPGITTKEELDWTKSAEDFARMNGEKVHYQWCIEDPYELN 
           __________________________________________________ 

           _______________________________                    
 2ikf(B) : LNVGRNVTPLKRDFLRRHLEKARDTALLTI*                    
         :                                                    
 2ikf(A) : LNVGRNVTPLKRDFLRRHLEKARDTALLTIV                    
           _______________________________                    

Details

  Property   Value
 Conformer 1 2ikf(B)
 Conformer 2 2ikf(A)
 Radius gyration for conformer 1 20.12 A
 Radius gyration for conformer 2 19.49 A
 EC Number 2.7.7.52  
Click here to see the DynDom results or the famliy
 Trigger ligands UTP501
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ASN147  ASN192  ASP66  ASP68  GLY144  GLY53  LYS169  LYS173  PHE52  SER148  SER188  SER54  SER65  THR187  TYR189 
 Residues in extended bending regions contacting ligands GLY53  PHE52 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT