RuvB
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1hqc(A) : ALRPKTLDEYIGQERLKQKLRVYLEAAKARKEPLEHLLLFGPPGLGKTTL 
         :                                                    
 1ixr(C) : ALRPKTLDEYIGQERLKQKLRVYLEAAKARKEPLEHLLLFGPPGLGKTTL 
           __________________________________________________ 

           _______________________79_____________________103_ 
 1hqc(A) : AHVIAHELGVNLRVTSGPAIEKPGDLAAILANSLEEGDILFIDEIHRLSR 
         :                                                    
 1ixr(C) : AHVIAHELGVNLRVTSGPAIEKPGDLAAILANSLEEGDILFIDEIHRLSR 
           _______________________79_____________________103_ 

           ___110____117_______________135___________________ 
 1hqc(A) : QAEEHLYPAMEDFVMDIVIGQGPAARTIRLELPRFTLIGATTRPGLITAP 
         :                                                    
 1ixr(C) : QAEEHLYPAMEDFVMDIVIGQGPAARTIRLELPRFTLIGATTRPGLITAP 
           ___110____117_______________135___________________ 

           __________________________________________________ 
 1hqc(A) : LLSRFGIVEHLEYYTPEELAQGVMRDARLLGVRITEEAALEIGRRSRGTM 
         :                                                    
 1ixr(C) : LLSRFGIVEHLEYYTPEELAQGVMRDARLLGVRITEEAALEIGRRSRGTM 
           __________________________________________________ 

           __________________________________________________ 
 1hqc(A) : RVAKRLFRRVRDFAQVAGEEVITRERALEALAALGLDELGLEKRDREILE 
         :                                                    
 1ixr(C) : RVAKRLFRRVRDFAQVAGEEVITRERALEALAALGLDELGLEKRDREILE 
           __________________________________________________ 

           __________________________________________________ 
 1hqc(A) : VLILRFGGGPVGLATLATALSEDPGTLEEVHEPYLIRQGLLKRTPRGRVP 
         :                                                    
 1ixr(C) : VLILRFGGGPVGLATLATALSEDPGTLEEVHEPYLIRQGLLKRTPRGRVA 
           __________________________________________________ 

           ______________                                     
 1hqc(A) : TELAYRHLGYPPPV                                     
         :                                                    
 1ixr(C) : TELARRHL******                                     
           ______________                                     

Details

  Property   Value
 Conformer 1 1hqc(A)
 Conformer 2 1ixr(C)
 Radius gyration for conformer 1 23.11 A
 Radius gyration for conformer 2 23.04 A
 EC Number 3.6.1.3  
Click here to see the DynDom results or the famliy
 Trigger ligands ANP1
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands No
 Residues in enzyme contacting ligands ARG205  ARG7  GLY48  GLY50  ILE15  LYS208  LYS51  MET204  THR52  THR53  TYR14 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT