ALCOHOL DEHYDROGENASE
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1n8k(A) : STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDD 
         :                                                    
 1ye3(A) : STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDD 
           __________________________________________________ 

           __________________________________________________ 
 1n8k(A) : HVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKC 
         :                                                    
 1ye3(A) : HVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKC 
           __________________________________________________ 

           __________________________________________________ 
 1n8k(A) : RVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYT 
         :                                                    
 1ye3(A) : RVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYT 
           __________________________________________________ 

           _______________________176________________________ 
 1n8k(A) : VVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGL 
         :                                                    
 1ye3(A) : VVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGL 
           _______________________176________________________ 

           __________________________________________________ 
 1n8k(A) : GGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPI 
         :                                                    
 1ye3(A) : GGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPI 
           __________________________________________________ 

           ______________________________________291_________ 
 1n8k(A) : QEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVITGVPPDSQN 
         :                                                    
 1ye3(A) : QEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQN 
           ______________________________________291_________ 

           ______________317________________336______________ 
 1n8k(A) : LSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVL 
         :                                                    
 1ye3(A) : LSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVL 
           ______________317________________336______________ 

           ________________________                           
 1n8k(A) : PFEKINEGFDLLRSGESIRTILTF                           
         :                                                    
 1ye3(A) : PFEKINEGFDLLRSGESIRTILTF                           
           ________________________                           

Details

  Property   Value
 Conformer 1 1n8k(A)
 Conformer 2 1ye3(A)
 Radius gyration for conformer 1 20.6 A
 Radius gyration for conformer 2 20.9 A
 EC Number 1.1.1.1  
Click here to see the DynDom results or the famliy
 Trigger ligands NAJ377
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA317  ARG271  ARG369  ARG47  ASN225  ASP223  CYS174  CYS46  GLY199  GLY201  GLY202  GLY270  GLY293  HIS51  ILE224  ILE269  ILE318  LEU200  LEU362  LYS228  PHE319  PHE93  SER48  THR178  THR292  VAL203  VAL268  VAL294 
 Residues in extended bending regions contacting ligands ALA317  CYS174  GLY293  ILE318  PHE319  THR178  THR292  VAL294 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ALA317  PHE319  THR178  THR292  VAL294 
  Residues in extended bending regions with an H-bond between its main chain and ligands ALA317  PHE319  THR292  VAL294 
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT