ANTHRANILATE SYNTHASE
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1i7s(C) : TKPQLTLLKVQASYRGDPTTLFHQLCGARPATLLLESAE------lQSLL 
         :                                                    
 1i7q(A) : TKPQLTLLKVQASYRGDPTTLFHQLCGARPATLLLESAEINDKQNLQSLL 
           __________________________________________________ 

           __________________________________________________ 
 1i7s(C) : VIDSALRITALGHTVSVQALTANGPALLPLLDEALPPEVRNQARPNGREL 
         :                                                    
 1i7q(A) : VIDSALRITALGHTVSVQALTANGPALLPLLDEALPPEVRNQARPNGREL 
           __________________________________________________ 

           __________________________________________________ 
 1i7s(C) : TFPAIDAVQDEDARLRSLSVFDALRTILTLVDSPADEREAVMLGGLFAYD 
         :                                                    
 1i7q(A) : TFPAIDAVQDEDARLRSLSVFDALRTILTLVDSPADEREAVMLGGLFAYD 
           __________________________________________________ 

           __________________________________________________ 
 1i7s(C) : LVAGFENLPALRQDQRCPDFCFYLAETLLVLDHQRGSARLQASVFSEQAS 
         :                                                    
 1i7q(A) : LVAGFENLPALRQDQRCPDFCFYLAETLLVLDHQRGSARLQASVFSEQAS 
           __________________________________________________ 

           __________________________________________________ 
 1i7s(C) : EAQRLQHRLEQLQAELQQPPQPIPHQKLENMQLSCNQSDEEYGAVVSELQ 
         :                                                    
 1i7q(A) : EAQRLQHRLEQLQAELQQPPQPIPHQKLENMQLSCNQSDEEYGAVVSELQ 
           __________________________________________________ 

           __________________________________________________ 
 1i7s(C) : EAIRQGEIFQVVPSRRFSLPCPAPLGPYQTLKDNNPSPYMFFMQDDDFTL 
         :                                                    
 1i7q(A) : EAIRQGEIFQVVPSRRFSLPCPAPLGPYQTLKDNNPSPYMFFMQDDDFTL 
           __________________________________________________ 

           306______315__320_________________________________ 
 1i7s(C) : FGASPESALKYDAGNRQIEIYPIAGTRPRGRRADGSLDLDLDSRIELEMR 
         :                                                    
 1i7q(A) : FGASPESALKYDAGNRQIEIYPIAGTRPRGRRADGSLDLDLDSRIELEMR 
           306______315__320_________________________________ 

           ___________________375____________________________ 
 1i7s(C) : TDHKELAEHLMLVDLARNDLARICQAGSRYVADLTKVDRYSFVMHLVSRV 
         :                                                    
 1i7q(A) : TDHKELAEHLMLVDLARNDLARICQAGSRYVADLTKVDRYSFVMHLVSRV 
           ___________________375____________________________ 

           _407____414_______________________________________ 
 1i7s(C) : VGTLRADLDVLHAYQACMNMGTLSGAPKVRAMQLIAALRSTRRGSYGGRV 
         :                                                    
 1i7q(A) : VGTLRADLDVLHAYQACMNMGTLSGAPKVRAMQLIAALRSTRRGSYGGRV 
           _407____414_______________________________________ 

           __________________________________________________ 
 1i7s(C) : GYFTAVRNLDTCIVIRSAYVEDGHRTVQAGAGVVQDSIPEREADETRNKA 
         :                                                    
 1i7q(A) : GYFTAVRNLDTCIVIRSAYVEDGHRTVQAGAGVVQDSIPEREADETRNKA 
           __________________________________________________ 

           _________________                                  
 1i7s(C) : RAVLRAIATAHHAKEVF                                  
         :                                                    
 1i7q(A) : RAVLRAIATAHHAKEVF                                  
           _________________                                  

Details

  Property   Value
 Conformer 1 1i7s(C)
 Conformer 2 1i7q(A)
 Radius gyration for conformer 1 22.64 A
 Radius gyration for conformer 2 22.58 A
 EC Number 4.1.3.27  
Click here to see the DynDom results or the famliy
 Trigger ligands PYR1601
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands No
 Residues in enzyme contacting ligands ALA482  ARG469  GLY483  ILE468  LYS502  TYR449  VAL265 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT