Dihydrodipicolinate reductase
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1yl7(C) : ARVGVLGAKGKVGATMVRAVAAADDLTLSAELDAGDPLSLLTDGNTEVVI 
         :                                                    
 1p9l(A) : MRVGVLGAKGKVGTTMVRAVAAADDLTLSAELDAGDPLSLLTDGNTEVVI 
           __________________________________________________ 

           __________________________________________________ 
 1yl7(C) : DFTHPDVVMGNLEFLIDNGIHAVVGTTGFTAERFQQVESWLVAKPNTSVL 
         :                                                    
 1p9l(A) : DFTHPDVVMGNLEFLIDNGIHAVVGTTGFTAERFQQVESWLVAKPNTSVL 
           __________________________________________________ 

           __105_____________________________________________ 
 1yl7(C) : IAPNFAIGAVLSMHFAKQAARFFDSAEVIELHHPHKADAPSGTAARTAKL 
         :                                                    
 1p9l(A) : IAPNFAIGAVLSMHFAKQAARFFDSAEVIELHHPHKADAPSGTAARTAKL 
           __105_____________________________________________ 

           __________________________________________________ 
 1yl7(C) : IAEARKGLPPNPDATSTSLPGARGADVDGIPVHAVRLAGLVAHQEVLFGT 
         :                                                    
 1p9l(A) : IAEARKGLPPNPDATSTSLPGARGADVDGIPVHAVRLAGLVAHQEVLFGT 
           __________________________________________________ 

           ________211__________________________________      
 1yl7(C) : EGETLTIRHDSLDRTSFVPGVLLAVRRIAERPGLTVGLEPLLDLH      
         :                                                    
 1p9l(A) : EGETLTIRHDSLDRTSFVPGVLLAVRRIAERPGLTVGLEPLLDLH      
           ________211__________________________________      

Details

  Property   Value
 Conformer 1 1yl7(C)
 Conformer 2 1p9l(A)
 Radius gyration for conformer 1 20.35 A
 Radius gyration for conformer 2 19.13 A
 EC Number 1.3.1.26  
Click here to see the DynDom results or the famliy
 Trigger ligands PDC302
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA192  ASN104  ASP138  GLY142  HIS132  HIS133  LYS136  PHE217  PRO103  SER141  THR143  THR77 
 Residues in extended bending regions contacting ligands ASN104  PHE217  PRO103 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT