PROTEIN (N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOT
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1b6r(A) : MKQVCVLGNGQLGRMLRQAGEPLGIAVWPVGLDAEPAAVPFQQSVITAEI 
         :                                                    
 1b6s(B) : MKQVCVLGNGQLGRMLRQAGEPLGIAVWPVGLDAEPAAVPFQQSVITAEI 
           __________________________________________________ 

           _____________________________________________97___ 
 1b6r(A) : ERWPETALTRQLARHPAFVNRDVFPIIADRLTQKQLFDKLHLPTAPWQLL 
         :                                                    
 1b6s(B) : ERWPETALTRELARHPAFVNRDVFPIIADRLTQKQLFDKLHLPTAPWQLL 
           _____________________________________________97___ 

           _________________120___________________142________ 
 1b6r(A) : AERSEWPAVFDRLGELAIVKRRTg------QWRLRANETEQLPAECYGEC 
         :                                                    
 1b6s(B) : AERSEWPAVFDRLGELAIVKRRTGGYDGRGQWRLRANETEQLPAECYGEC 
           _________________120___________________142________ 

           153_______________________________________________ 
 1b6r(A) : IVEQGINFSGEVSLVGARGFDGSTVFYPLTHNLHQDGILRTSVAFPQANA 
         :                                                    
 1b6s(B) : IVEQGINFSGEVSLVGARGFDGSTVFYPLTHNLHQDGILRTSVAFPQANA 
           153_______________________________________________ 

           __________________________________________________ 
 1b6r(A) : QQQARAEEMLSAIMQELGYVGVMAMECFVTPQGLLINELAPRVHNSGHWT 
         :                                                    
 1b6s(B) : QQQARAEEMLSAIMQELGYVGVMAMECFVTPQGLLINELAPRVHNSGHWT 
           __________________________________________________ 

           __________________________________________________ 
 1b6r(A) : QNGASISQFELHLRAITDLPLPQPVVNNPSVMINLIGSDVNYDWLKLPLV 
         :                                                    
 1b6s(B) : QNGASISQFELHLRAITDLPLPQPVVNNPSVMINLIGSDVNYDWLKLPLV 
           __________________________________________________ 

           __________________________________________________ 
 1b6r(A) : HLHWYDKEVRPGRKVGHLNLTDSDTSRLTATLEALIPLLPPEYASGVIWA 
         :                                                    
 1b6s(B) : HLHWYDKEVRPGRKVGHLNLTDSDTSRLTATLEALIPLLPPEYASGVIWA 
           __________________________________________________ 

           _____                                              
 1b6r(A) : QSKFG                                              
         :                                                    
 1b6s(B) : QSKFG                                              
           _____                                              

Details

  Property   Value
 Conformer 1 1b6r(A)
 Conformer 2 1b6s(B)
 Radius gyration for conformer 1 20.93 A
 Radius gyration for conformer 2 20.62 A
 EC Number 4.1.1.21  
Click here to see the DynDom results or the famliy
 Trigger ligands ADP1200
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ARG129  ARG133  ARG80  ASN237  ASP127  GLN131  GLN154  GLU153  GLU161  GLU238  GLY125  GLY128  GLY155  HIS184  ILE118  ILE156  LYS120  PHE158  PHE228  TYR126 
 Residues in extended bending regions contacting ligands ARG129  ARG133  ASP127  GLN131  GLN154  GLU153  GLY125  GLY128  GLY155  ILE118  ILE156  LYS120  TYR126 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ASP127  GLN131  GLN154  GLU153  GLY125  GLY128  ILE156  LYS120  TYR126 
  Residues in extended bending regions with an H-bond between its main chain and ligands GLN154  GLY125  GLY128  ILE156  TYR126 
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT