CCA-adding enzyme
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1tfy(D) : MKVEEILEKALELVIPDEEEVRKGREAEEELRRRLDELGVEYVFVGSYAR 
         :                                                    
 2dra(A) : MKVEEILEKALELVIPDEEEVRKGREAEEELRRRLDELGVEYVFVGSYAR 
           __________________________________________________ 

           __________________________________________________ 
 1tfy(D) : NTWLKGSLEIDVFLLFPEEFSKEELRERGLEIGKAVLDSYEIRYAEHPYV 
         :                                                    
 2dra(A) : NTWLKGSLEIDVFLLFPEEFSKEELRERGLEIGKAVLDSYEIRYAEHPYV 
           __________________________________________________ 

           __________________________________________________ 
 1tfy(D) : HGVVKGVEVDVVPCYKLKEPKNIKSAVDRTPFHHKWLEGRIKGKENEVRL 
         :                                                    
 2dra(A) : HGVVKGVEVDVVPCYKLKEPKNIKSAVDRTPFHHKWLEGRIKGKENEVRL 
           __________________________________________________ 

           __________163_167_________________________________ 
 1tfy(D) : LKGFLKANGIYGAEYKVRGFSGYLCELLIVFYGSFLETVKNARRWTRRTV 
         :                                                    
 2dra(A) : LKGFLKANGIYGAEYKVRGFSGYLCELLIVFYGSFLETVKNARRWTRRTV 
           __________163_167_________________________________ 

           __________________________________________________ 
 1tfy(D) : IDVAKGEVRKGEEFFVVDPVDEKRNVAANLSLDNLARFVHLCREFMEAPS 
         :                                                    
 2dra(A) : IDVAKGEVRKGEEFFVVDPVDEKRNVAANLSLDNLARFVHLCREFMEAPS 
           __________________________________________________ 

           ___256____________________________________________ 
 1tfy(D) : LGFFKPKHPLEIEPERLRKIVEERGTAVFAVKFRKPDIVDDNLYPQLERA 
         :                                                    
 2dra(A) : LGFFKPKHPLEIEPERLRKIVEERGTAVFAVKFRKPDIVDDNLYPQLERA 
           ___256____________________________________________ 

           __________________________________________________ 
 1tfy(D) : SRKIFEFLERENFMPLRSAFKASEEFCYLLFECQIKEISRVFRRMGPQFE 
         :                                                    
 2dra(A) : SRKIFEFLERENFMPLRSAFKASEEFCYLLFECQIKEISRVFRRMGPQFE 
           __________________________________________________ 

           __________________________________________________ 
 1tfy(D) : DERNVKKFLSRNRAFRPFIENGRWWAFEMRKFTTPEEGVRSYASTHWHTL 
         :                                                    
 2dra(A) : DERNVKKFLSRNRAFRPFIENGRWWAFEMRKFTTPEEGVRSYASTHWHTL 
           __________________________________________________ 

           _____________________________________              
 1tfy(D) : GKNVGESIREYFEIISGEKLFKEPVTAELCEMMGVKD              
         :                                                    
 2dra(A) : GKNVGESIREYFEIISGEKLFKEPVTAELCEMMGVKD              
           _____________________________________              

Details

  Property   Value
 Conformer 1 1tfy(D)
 Conformer 2 2dra(A)
 Radius gyration for conformer 1 27.59 A
 Radius gyration for conformer 2 27.69 A
 EC Number 2.7.7.25   2.7.7.21  
Click here to see the DynDom results or the famliy
 Trigger ligands CTP504
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA163  ARG224  ARG50  ASP61  GLU59  GLY46  HIS133  LYS152  SER171  SER47  THR130  TYR161  TYR173 
 Residues in extended bending regions contacting ligands ALA163  SER171  TYR161 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands TYR161 
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT