Alpha-ketoglutarate-dependent taurine dioxyge
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1otj(D) : ERLSITPLGPYIGAQISGADLTRPLSDNQFEQLYHAVLRHQVVFLRDQAI 
         :                                                    
 1otj(C) : ERLSITPLGPYIGAQISGADLTRPLSDNQFEQLYHAVLRHQVVFLRDQAI 
           __________________________________________________ 

           __________________________________________________ 
 1otj(D) : TPQQQRALAQRFGELHIHPVYPHAEGVDEIIVLDTHNDNPPDNDNWHTDV 
         :                                                    
 1otj(C) : TPQQQRALAQRFGELHIHPVYPHAEGVDEIIVLDTHNDNPPDNDNWHTDV 
           __________________________________________________ 

           ________________________________________________15 
 1otj(D) : TFIETPPAGAILAAKELPSTGGDTLWTSGIAAYEALSVPFRQLLSGLRAE 
         :                                                    
 1otj(C) : TFIETPPAGAILAAKELPSTGGDTLWTSGIAAYEALSVPFRQLLSGLRAE 
           ________________________________________________15 

           3___________________________183___________________ 
 1otj(D) : HDFRKSFPEYKYRKTEEEHQRWREAVAKNPPLLHPVVRTHPVSGKQALFV 
         :                                                    
 1otj(C) : HDFRKSFPEYKYRKTEEEHQRWREAVAKNPPLLHPVVRTHPVSGKQALFV 
           3___________________________183___________________ 

           __________________________________________________ 
 1otj(D) : NEGFTTRIVDVSEKESEALLSFLFAHITKPEFQVRWRWQPNDIAIWDNRV 
         :                                                    
 1otj(C) : NEGFTTRIVDVSEKESEALLSFLFAHITKPEFQVRWRWQPNDIAIWDNRV 
           __________________________________________________ 

           ______________________________                     
 1otj(D) : TQHYANADYLPQRRIMHRATILGDKPFYRA                     
         :                                                    
 1otj(C) : TQHYANADYLPQRRIMHRATILGDKPFYRA                     
           ______________________________                     

Details

  Property   Value
 Conformer 1 1otj(D)
 Conformer 2 1otj(C)
 Radius gyration for conformer 1 18.88 A
 Radius gyration for conformer 2 18.62 A
 EC Number 1.14.11.17  
Click here to see the DynDom results or the famliy
 Trigger ligands TAU954
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ARG270  ASN95  ASP101  HIS70  HIS99  PHE104  PHE159  PHE206  TYR73  VAL102 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT