Gluconate kinase
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           ________________________________36________________ 
 1ko5(B) : TTNHDHHIYVLMGVSGSGKSAVASEVAHQLHAAFLDGDFLHPRRNIEKMA 
         :                                                    
 1knq(A) : TTNHDHHIYVLMGVSGSGKSAVASEVAHQLHAAFLDGDFLHPRRNIEKMA 
           ________________________________36________________ 

           _________________71_______________________________ 
 1ko5(B) : SGEPLNDDDRKPWLQALNDAAFAMQRTNKVSLIVCSALKKHYRDLLREGN 
         :                                                    
 1knq(A) : SGEPLNDDDRKPWLQALNDAAFAMQRTNKVSLIVCSALKKHYRDLLREGN 
           _________________71_______________________________ 

           __________________________________________________ 
 1ko5(B) : PNLSFIYLKGDFDVIESRLKARKGHFFKTQMLVTQFETLQEPGADETDVL 
         :                                                    
 1knq(A) : PNLSFIYLKGDFDVIESRLKARKGHFFKTQMLVTQFETLQEPGADETDVL 
           __________________________________________________ 

           ______________________                             
 1ko5(B) : VVDIDQPLEGVVASTIEVIKKG                             
         :                                                    
 1knq(A) : VVDIDQPLEGVVASTIEVIKK*                             
           ______________________                             

Details

  Property   Value
 Conformer 1 1ko5(B)
 Conformer 2 1knq(A)
 Radius gyration for conformer 1 16.11 A
 Radius gyration for conformer 2 15.77 A
 EC Number 2.7.1.12  
Click here to see the DynDom results or the famliy
 Trigger ligands ATP303
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact No
 Spanning ligands No
 Residues in enzyme contacting ligands ALA23  ARG120  ARG124  GLN158  GLY18  GLY20  ILE156  LEU160  LYS21  PRO159  SER17  SER19  SER22  VAL16  VAL163 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT