GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTR
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1ecc(B) : CGIVGIAGVMPVNQSIYDALTVLQHRGQDAAGIITIDANNCFRLRKANGL 
         :                                                    
 1ecf(B) : CGIVGIAGVMPVNQSIYDALTVLQHRGQDAAGIITIDANNCFRLRKANGL 
           __________________________________________________ 

           __________________________________________________ 
 1ecc(B) : VSDVFEARHMQRLQGNMGIGHVRYPTAGSSSASEAQPFYVNSPYGITLAH 
         :                                                    
 1ecf(B) : VSDVFEARHMQRLQGNMGIGHVRYPTAGSSSASEAQPFYVNSPYGITLAH 
           __________________________________________________ 

           __________________________________________________ 
 1ecc(B) : NGNLTNAHELRKKLFEEKRRHINTTSDSEILLNIFASELDNFRHYPLEAD 
         :                                                    
 1ecf(B) : NGNLTNAHELRKKLFEEKRRHINTTSDSEILLNIFASELDNFRHYPLEAD 
           __________________________________________________ 

           __________________________________________________ 
 1ecc(B) : NIFAAIAATNRLIRGAYACVAMIIGHGMVAFRDPNGIRPLVLGKRDIDEN 
         :                                                    
 1ecf(B) : NIFAAIAATNRLIRGAYACVAMIIGHGMVAFRDPNGIRPLVLGKRDIDEN 
           __________________________________________________ 

           __________________________________________________ 
 1ecc(B) : RTEYMVASESVALDTLGFDFLRDVAPGEAIYITEEGQLFTRQCADNPVSN 
         :                                                    
 1ecf(B) : RTEYMVASESVALDTLGFDFLRDVAPGEAIYITEEGQLFTRQCADNPVSN 
           __________________________________________________ 

           __________________________________________________ 
 1ecc(B) : PCLFEYVYFARPDSFIDKISVYSARVNMGTKLGEKIAREWEDLDIDVVIP 
         :                                                    
 1ecf(B) : PCLFEYVYFARPDSFIDKISVYSARVNMGTKLGEKIAREWEDLDIDVVIP 
           __________________________________________________ 

           _______________________326_______________344______ 
 1ecc(B) : IPETSCDIALEIARILGKPYRQGFVKNRYVGRTFIMPGQQLRRKSVRRKL 
         :                                                    
 1ecf(B) : IPETSCDIALEIARILGKPYRQGFVKNRYVGRTFIMPGQQLRRKSVRRKL 
           _______________________326_______________344______ 

           __________________________________________________ 
 1ecc(B) : NANRAEFRDKNVLLVDDSIVRGTTSEQIIEMAREAGAKKVYLASAAPEIR 
         :                                                    
 1ecf(B) : NANRAEFRDKNVLLVDDSIVRGTTSEQIIEMAREAGAKKVYLASAAPEIR 
           __________________________________________________ 

           __________________________________________________ 
 1ecc(B) : FPNVYGIDMPSATELIAHGREVDEIRQIIGADGLIFQDLNDLIDAVRAEN 
         :                                                    
 1ecf(B) : FPNVYGIDMPSATELIAHGREVDEIRQIIGADGLIFQDLNDLIDAVRAEN 
           __________________________________________________ 

           __________________________________________________ 
 1ecc(B) : PDIQQFECSVFNGVYVTKDVDQGYLDFLDTLRNDDAKAVQRQ******** 
         :                                                    
 1ecf(B) : PDIQQFECSVFNGVYVTKDVDQGYLDFLDTLRNDDAKAVQRQNEVENLEM 
           __________________________________________________ 

Details

  Property   Value
 Conformer 1 1ecc(B)
 Conformer 2 1ecf(B)
 Radius gyration for conformer 1 22.98 A
 Radius gyration for conformer 2 23.87 A
 EC Number 2.4.2.14  
Click here to see the DynDom results or the famliy
 Trigger ligands PCP505
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ARG332  ARG371  ASP366  ASP367  GLU303  GLY372  ILE369  LYS349  PHE334  PRO302  SER368  THR304  THR333  THR373  THR374  TYR258  VAL370 
 Residues in extended bending regions contacting ligands LYS349 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands LYS349 
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT