L-allo-threonine aldolase
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           _______6__________________________________________ 
 2fm1(D) : HHMIDLRSDTVTKPTEEMRKAMAQAEVGDDVYGEDPTINELERLAAETFG 
         :                                                    
 1lw5(A) : ***IDLRSDTVTKPTEE-rKA-aQAEVGDDVYGEDPTINELERLAAETFG 
           _______6__________________________________________ 

           __________________________________________________ 
 2fm1(D) : KEAALFVPSGTMGNQVSIMAHTQRGDEVILEADSHIFWYEVGAMAVLSGV 
         :                                                    
 1lw5(A) : KEAALFVPSGT-gNQVSI-aHTQRGDEVILEADSHIFWYEVGA-aVLSGV 
           __________________________________________________ 

           __________________________________________________ 
 2fm1(D) : MPHPVPGKNGAMDPDDVRKAIRPRNIHFPRTSLIAIENTHNRSGGRVVPL 
         :                                                    
 1lw5(A) : -pHPVPGKNGA-dPDDVRKAIRPRNIHFPRTSLIAIENTHNRSGGRVVPL 
           __________________________________________________ 

           __________________________________________________ 
 2fm1(D) : ENIKEICTIAKEHGINVHIDGARIFNASIASGVPVKEYAGYADSVMFCLS 
         :                                                    
 1lw5(A) : ENIKEICTIAKEHGINVHIDGARIFNASIASGVPVKEYAGYADSV-fCLS 
           __________________________________________________ 

           __________________________________________________ 
 2fm1(D) : gLCAPVGSVVVGDRDFIERARKARKMLGGGMRQAGVLAAAGIIALTKMVD 
         :                                                    
 1lw5(A) : gLCAPVGSVVVGDRDFIERARKARK-lGGG-rQAGVLAAAGIIALTK-vD 
           __________________________________________________ 

           __254_____________________________________________ 
 2fm1(D) : RLKEDHENARFLALKLKEIGYSVNPEDVKTNMVILRTDNLKVNAHGFIEA 
         :                                                    
 1lw5(A) : RLKEDHENARFLALKLKEIGYSVNPEDVKTN-vILRTDNLKVNAHGFIEA 
           __254_____________________________________________ 

           ____________________________________________       
 2fm1(D) : LRNSGVLANAVSDTEIRLVTHKDVSRNDIEEALNIFEKLFRKFS       
         :                                                    
 1lw5(A) : LRNSGVLANAVSDTEIRLVTHKDVSRNDIEEALNIFEKLFRKFS       
           ____________________________________________       

Details

  Property   Value
 Conformer 1 2fm1(D)
 Conformer 2 1lw5(A)
 Radius gyration for conformer 1 20.85 A
 Radius gyration for conformer 2 21.16 A
 EC Number 4.1.2.5  
Click here to see the DynDom results or the famliy
 Trigger ligands PLG1002
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact No
 Spanning ligands No
 Residues in enzyme contacting ligands ARG231 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT