Methyltransferase 1
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 2i2x(J) : MLDFTEASLKKVLTRYNVALEKALTPEEAAEELYPKDELIYPIAKAIFEG 
         :                                                    
 2i2x(B) : MLDFTEASLKKVLTRYNVALEKALTPEEAAEELYPKDELIYPIAKAIFEG 
           __________________________________________________ 

           __________________________________________________ 
 2i2x(J) : EEDDVVEGLQAAIEAGKDPIDLIDDALMVGMGVVIRLYDEGVIFLPNVMM 
         :                                                    
 2i2x(B) : EEDDVVEGLQAAIEAGKDPIDLIDDALMVGMGVVIRLYDEGVIFLPNVMM 
           __________________________________________________ 

           _______110________________________________________ 
 2i2x(J) : SADAMLEGIEYCKENSGATPKTKGTVVCHVAEGDVHDIGKNIVTALLRAN 
         :                                                    
 2i2x(B) : SADAMLEGIEYCKENSGATPKTKGTVVCHVAEGDVHDIGKNIVTALLRAN 
           _______110________________________________________ 

           __________________________________________________ 
 2i2x(J) : GYNVVDLGRDVPAEEVLAAVQKEKPIMLTGTALMTTTMYAFKEVNDMLLE 
         :                                                    
 2i2x(B) : GYNVVDLGRDVPAEEVLAAVQKEKPIMLTGTALMTTTMYAFKEVNDMLLE 
           __________________________________________________ 

           __________________________________________________ 
 2i2x(J) : NGIKIPFACGGGAVNQDFVSQFALGVYGEEAADAPKIADAIIAGTTDVTE 
         :                                                    
 2i2x(B) : NGIKIPFACGGGAVNQDFVSQFALGVYGEEAADAPKIADAIIAGTTDVTE 
           __________________________________________________ 

           ________                                           
 2i2x(J) : LREKFHKH                                           
         :                                                    
 2i2x(B) : LREKFHKH                                           
           ________                                           

Details

  Property   Value
 Conformer 1 2i2x(J)
 Conformer 2 2i2x(B)
 Radius gyration for conformer 1 21.44 A
 Radius gyration for conformer 2 21.61 A
 EC Number 2.1.1.90  
Click here to see the DynDom results or the famliy
 Trigger ligands B13500
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact No
 Spanning ligands No
 Residues in enzyme contacting ligands
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT