NAD(P) transhydrogenase subunit alpha part 1
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           _____________________________________39_42________ 
 1u28(A) : MKIAIPKERRPGEDRVAISPEVVKKLVGLGFEVIVEQGAGVGASITDDAL 
         :                                                    
 1l7d(B) : MKIAIPKERRPGEDRVAISPEVVKKLVGLGFEVIVEQGAGVGASITDDAL 
           ____________________________________439___________ 

           __________________________________________________ 
 1u28(A) : TAAGATIASTAAQALSQADVVWKVQRPMTAEEGTDEVALIKEGAVLMCHL 
         :                                                    
 1l7d(B) : TAAGATIASTAAQALSQADVVWKVQRPMTAEEGTDEVALIKEGAVLMCHL 
           __________________________________________________ 

           _______________________________134_138____________ 
 1u28(A) : GALTNRPVVEALTKRKITAYAMELMPRISRAQSMDILSSQSNLAGYRAVI 
         :                                                    
 1l7d(B) : GALTNRPVVEALTKRKITAYAMELMPRISRAQSMDILSSQSNLAGYRAVI 
           _______________________________534_538____________ 

           __________________________________________________ 
 1u28(A) : DGAYEFARAFPMMMTAAGTVPPARVLVFGVGVAGLQAIATAKRLGAVVMA 
         :                                                    
 1l7d(B) : DGAYEFARAFPMMMTAAGTVPPARVLVFGVGVAGLQAIATAKRLGAVVMA 
           __________________________________________________ 

           __________________________________________________ 
 1u28(A) : TDVRAATKEQVESLGGKFITVDDEAMKTAETAGGYAKEMGEEFRKKQAEA 
         :                                                    
 1l7d(B) : TDVRAATKEQVESLGGKFIT-------------------------kQAEA 
           __________________________________________________ 

           __________________________________________________ 
 1u28(A) : VLKELVKTDIAITTALIPGKPAPVLITEEMVTKMKPGSVIIDLAVEAGGN 
         :                                                    
 1l7d(B) : VLKELVKTDIAITTALIPGKPAPVLITEEMVTKMKPGSVIIDLAVEAGGN 
           __________________________________________________ 

           _______________________________334________________ 
 1u28(A) : CPLSEPGKIVVKHGVKIVGHTNVPSRVAADASPLFAKNLLNFLTPHVDKD 
         :                                                    
 1l7d(B) : CPLSEPGKIVVKHGVKIVGHTNVPSRVAADASPLFAKNLLNFLTPHVDKD 
           _______________________________734________________ 

           _________________________________                  
 1u28(A) : TKTLVMKLEDETVSGTCVTRDGAIVHPA*****                  
         :                                                    
 1l7d(B) : TKTLVMKLEDETVSGTCVTRDGAIVHPALTGQG                  
           _________________________________                  

Details

  Property   Value
 Conformer 1 1u28(A)
 Conformer 2 1l7d(B)
 Radius gyration for conformer 1 22.39 A
 Radius gyration for conformer 2 22.31 A
 EC Number 1.6.1.2   1.6.1.1  
Click here to see the DynDom results or the famliy
 Trigger ligands NAD500
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact No
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA236  ALA265  ARG127  ARG204  ASP135  ASP202  GLN132  GLN247  GLY179  GLY181  GLY234  ILE128  LEU266  LEU275  PRO126  PRO273  SER129  SER138  THR264  VAL180  VAL182  VAL203 
 Residues in extended bending regions contacting ligands ASP135  GLN132  SER138 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT